Structural Glycobiology

Herausgeber: Ramsland, Paul A.; Yuriev, Elizabeth

• Gebundenes Buch

Produktbeschreibung

Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is illustrated throughout by specific examples of how research investigations have yielded key structural and associated biological data on carbohydrates and glycolipids. In particular, the book focuses on: X-ray crystallography and small-angle scattering, NMR, and cryo-electron microscopy techniques Theoretical (modeling-based) approaches, such as molecular mechanics, molecular dynamics, free energy calculations, and carbohydrate docking Alternative techniques for yielding structural information on carbohydrates from complex biological samples Carbohydrates in medicine, specifically in areas that have been directly impacted by our understanding of the structural role of carbohydrates in immune recognition: cancer, organ transplantation, and infection

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Produktdetails

• Verlag: CRC Press
• Seitenzahl: 348
• Erscheinungstermin: 27. September 2012
• Englisch
• Abmessung: 240mm x 161mm x 23mm
• Gewicht: 689g
• ISBN-13: 9781439854600
• ISBN-10: 1439854602
• Artikelnr.: 32800956

Autorenporträt

Elizabeth Yuriev is with the Monash Institute for Pharmaceutical Sciences at Monash University, Australia. Paul A. Ramsland is with the Centre for Immunology at the Burnet Institute in Melbourne, Australia.

Inhaltsangabe

Experimental Techniques to Determine Three-Dimensional Structures:
Crystallography and Small-Angle Scattering of Carbohydrate-Protein
Complexes and Glycoproteins. Nuclear Magnetic Resonance Studies of
Carbohydrate-Protein Interactions. Electron Cryomicroscopy of Large
Glycoprotein Assemblies. Theoretical/Modeling Techniques to Predict
Three-Dimensional Structures: Protein-Carbohydrate Interactions:
Computational Aspects. Docking of Carbohydrates into Protein Binding Sites.
Alternative Approaches for Yielding Detailed Structural Information: Mass
Spectrometry for Glycomics Analysis of N- and O-Linked Glycoproteins.
Glycan-Based Arrays for Determining Specificity of Carbohydrate-Binding
Proteins. Carbohydrates in Medicine: Structural Glycobiology: Applications
in Cancer Research. Structural Glycobiology: Applications in Organ
Transplantation. Structural Glycobiology: Applications in Viral Infection.
Developing Drugs from Sugars Current State of Glycosaminoglycan-Derived
Therapeutics.