Peter Tompa, Alan Fersht

Structure and Function of Intrinsically Disordered Proteins

• Gebundenes Buch

Produktbeschreibung

A detailed investigation into intrinsically disordered proteins (IDP), this seminal work illustrates how IDPs defy the structure-function paradigm and play important regulatory and signaling roles. Introducing basic terms and fundamental principals of protein science, the author presents a unified theory of ordered and disordered proteins and outlines new applications for traditional biophysical and bioinformatic techniques, such as x-ray crystallography and NMR. The book reviews the structure, function, and evolution of IDPs and considers biomedical implications as well as applications in drug development for cancer and neurodegenerative diseases.

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Produktdetails

• Verlag: Taylor & Francis Ltd (Sales)
• Seitenzahl: 360
• Erscheinungstermin: 1. November 2009
• Englisch
• Abmessung: 236mm x 163mm x 23mm
• Gewicht: 635g
• ISBN-13: 9781420078923
• ISBN-10: 1420078925
• Artikelnr.: 27430952

Autorenporträt

Peter Tompa is Group Leader in the Laboratory of Intrinsically Disordered Proteins, Institute of Enzymology, Biological Research Center at the Hungarian Academy of Sciences in Budapest.

Inhaltsangabe

Principles of Protein Structure and Function. A Brief History of Protein
Disorder. Indirect Techniques for Recognizing and Characterizing Protein
Disorder. Hydrodynamic Techniques. Spectroscopic Techniques for
Characterizing Disorder. Nuclear Magnetic Resonance. Proteomic Approaches
for the Identification of IDPs. IDPs under Conditions Approaching In Vivo.
Prediction of Disorder. Structure of IDPs. Biological Processes Enriched in
Disorder. Molecular Functions of Disordered Proteins. Evolution and
Prevalence of Disorder. Extension of the Structure-Function Paradigm.
Structural Disorder and Disease. References.