Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels
Eds.: Kaczmarek, Leonard K., Gribkoff, Valentin K.
Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels
Eds.: Kaczmarek, Leonard K., Gribkoff, Valentin K.
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This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.
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This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 496
- Erscheinungstermin: 1. Februar 2009
- Englisch
- Abmessung: 239mm x 155mm x 28mm
- Gewicht: 806g
- ISBN-13: 9780471930136
- ISBN-10: 047193013X
- Artikelnr.: 25447572
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 496
- Erscheinungstermin: 1. Februar 2009
- Englisch
- Abmessung: 239mm x 155mm x 28mm
- Gewicht: 806g
- ISBN-13: 9780471930136
- ISBN-10: 047193013X
- Artikelnr.: 25447572
VALENTIN K. GRIBKOFF, PHD, is the Chief Scientific Officer and Senior Vice President of Discovery Research at Knopp Neurosciences. He is also an Adjunct Associate Professor in the Department of Pharmacology at Yale University School of Medicine. Dr. Gribkoff has published 100 articles and holds twelve patents. LEONARD K. KACZMAREK, PHD, is a Professor in the Departments of Pharmacology and Molecular and Cellular Physiology at Yale University School of Medicine. Dr. Kaczmarek has edited or authored two books and over 200 articles. He has served on the editorial boards of The Journal of Neuroscience, Journal of Molecular Neuroscience, The Journal of Experimental Biology, and New Biologist.
Preface. Contributors. PART 1 NEURONAL VOLTAGE-GATED ION CHANNEL FUNCTIONS.
1 Neuronal L-Type Voltage-Gated Calcium Channels (Alexander Scriabine and
David J. Triggle). 2 Voltage-Gated N-Type and T-Type Calcium Channels and
Excitability Disorders (Elizabeth Tringham and Terrance P. Snutch). 3
Voltage-Gated Sodium Channels: Multiple Roles in the Pathophysiology of
Pain (Sulayman D. Dib-Hajj, Bryan C. Hains, Joel A. Black, and Stephen G.
Waxman). 4 The Role of Ion Channels in the Etiology and Development of
Gliomas (Amy K. Weaver and Harald Sontheimer). 5 Shaker Family Kv1
Voltage-Gated Potassium Channels in Mammalian Brain Neurons (Helene Vacher
and James S. Trimmer). 6 Unique Mitochondrial Ion Channels: Roles in
Synaptic Transmission and Programmed Cell Death (Elizabeth A. Jonas). 7
Regulation of Neuronal Excitability by the Sodium-Activated Potassium
Channels Slick (SLO2.1) and Slack (SLO2.2) (Valentin K. Gribkoff and
Leonard K. Kaczmarek). PART 2 MODULATORY MECHANISMS AND INFLUENCES ON
NEURONAL VOLTAGE-GATED ION CHANNEL FUNCTION. 8 Alternative Splicing of
Neuronal Cav2 Calcium Channels (Diane Lipscombe, Summer E. Allen, Annette
C. Gray, Spiro Marangoudakis, and Jesica Raingo). 9 Effect of
Hypoxia/Ischemia on Voltage-Dependent Channels (Xiang Q. Gu, Hang Yao, and
Gabriel G. Haddad). 10 In Vivo Roles of Ion Channel Regulatory Protein
Complexes in Neuronal Physiology and Behavior (Smitha Reddy, Mohammad
Shahidullah, and Irwin B. Levitan). 11 Regulation of Neuronal Ion Channels
by G-Protein-Coupled Receptors in Sympathetic Neurons (Mark S. Shapiro and
Nikita Gamper). 12 BK Channels: Regulation of Expression and Physiological
Impact (P. Kundu, A. Alioua, Y. Kumar, R. Lu, J. Ou, E. Sanchez-Pastor, M.
Li, E. Stefani, and L. Toro). 13 Structural Basis for Auxiliary KChIP
Modulation of Kv4 Channels (KeWei Wang and Jijie Chai). PART 3 DRUG
DISCOVERY TARGETS AND TECHNOLOGY. 14 Sodium Channel Blockers for the
Treatment of Chronic Pain (Mark R. Bowlby and Edward Kaftan). 15 Neuronal
Kv7 Potassium Channels as Emerging Targets for the Treatment of Pain
(Steven I. Dworetzky and Valentin K. Gribkoff). 16 Small-Molecule
Modulators of Large-Conductance, Calcium-Activated (BK) Channels (John E.
Starrett Jr.). 17 High-Throughput Screening Technologies in Ion Channel
Drug Discovery (Edward B. Stevens, Andrew D. Whyment, and J. Mark
Treherne). Index.
1 Neuronal L-Type Voltage-Gated Calcium Channels (Alexander Scriabine and
David J. Triggle). 2 Voltage-Gated N-Type and T-Type Calcium Channels and
Excitability Disorders (Elizabeth Tringham and Terrance P. Snutch). 3
Voltage-Gated Sodium Channels: Multiple Roles in the Pathophysiology of
Pain (Sulayman D. Dib-Hajj, Bryan C. Hains, Joel A. Black, and Stephen G.
Waxman). 4 The Role of Ion Channels in the Etiology and Development of
Gliomas (Amy K. Weaver and Harald Sontheimer). 5 Shaker Family Kv1
Voltage-Gated Potassium Channels in Mammalian Brain Neurons (Helene Vacher
and James S. Trimmer). 6 Unique Mitochondrial Ion Channels: Roles in
Synaptic Transmission and Programmed Cell Death (Elizabeth A. Jonas). 7
Regulation of Neuronal Excitability by the Sodium-Activated Potassium
Channels Slick (SLO2.1) and Slack (SLO2.2) (Valentin K. Gribkoff and
Leonard K. Kaczmarek). PART 2 MODULATORY MECHANISMS AND INFLUENCES ON
NEURONAL VOLTAGE-GATED ION CHANNEL FUNCTION. 8 Alternative Splicing of
Neuronal Cav2 Calcium Channels (Diane Lipscombe, Summer E. Allen, Annette
C. Gray, Spiro Marangoudakis, and Jesica Raingo). 9 Effect of
Hypoxia/Ischemia on Voltage-Dependent Channels (Xiang Q. Gu, Hang Yao, and
Gabriel G. Haddad). 10 In Vivo Roles of Ion Channel Regulatory Protein
Complexes in Neuronal Physiology and Behavior (Smitha Reddy, Mohammad
Shahidullah, and Irwin B. Levitan). 11 Regulation of Neuronal Ion Channels
by G-Protein-Coupled Receptors in Sympathetic Neurons (Mark S. Shapiro and
Nikita Gamper). 12 BK Channels: Regulation of Expression and Physiological
Impact (P. Kundu, A. Alioua, Y. Kumar, R. Lu, J. Ou, E. Sanchez-Pastor, M.
Li, E. Stefani, and L. Toro). 13 Structural Basis for Auxiliary KChIP
Modulation of Kv4 Channels (KeWei Wang and Jijie Chai). PART 3 DRUG
DISCOVERY TARGETS AND TECHNOLOGY. 14 Sodium Channel Blockers for the
Treatment of Chronic Pain (Mark R. Bowlby and Edward Kaftan). 15 Neuronal
Kv7 Potassium Channels as Emerging Targets for the Treatment of Pain
(Steven I. Dworetzky and Valentin K. Gribkoff). 16 Small-Molecule
Modulators of Large-Conductance, Calcium-Activated (BK) Channels (John E.
Starrett Jr.). 17 High-Throughput Screening Technologies in Ion Channel
Drug Discovery (Edward B. Stevens, Andrew D. Whyment, and J. Mark
Treherne). Index.
Preface. Contributors. PART 1 NEURONAL VOLTAGE-GATED ION CHANNEL FUNCTIONS.
1 Neuronal L-Type Voltage-Gated Calcium Channels (Alexander Scriabine and
David J. Triggle). 2 Voltage-Gated N-Type and T-Type Calcium Channels and
Excitability Disorders (Elizabeth Tringham and Terrance P. Snutch). 3
Voltage-Gated Sodium Channels: Multiple Roles in the Pathophysiology of
Pain (Sulayman D. Dib-Hajj, Bryan C. Hains, Joel A. Black, and Stephen G.
Waxman). 4 The Role of Ion Channels in the Etiology and Development of
Gliomas (Amy K. Weaver and Harald Sontheimer). 5 Shaker Family Kv1
Voltage-Gated Potassium Channels in Mammalian Brain Neurons (Helene Vacher
and James S. Trimmer). 6 Unique Mitochondrial Ion Channels: Roles in
Synaptic Transmission and Programmed Cell Death (Elizabeth A. Jonas). 7
Regulation of Neuronal Excitability by the Sodium-Activated Potassium
Channels Slick (SLO2.1) and Slack (SLO2.2) (Valentin K. Gribkoff and
Leonard K. Kaczmarek). PART 2 MODULATORY MECHANISMS AND INFLUENCES ON
NEURONAL VOLTAGE-GATED ION CHANNEL FUNCTION. 8 Alternative Splicing of
Neuronal Cav2 Calcium Channels (Diane Lipscombe, Summer E. Allen, Annette
C. Gray, Spiro Marangoudakis, and Jesica Raingo). 9 Effect of
Hypoxia/Ischemia on Voltage-Dependent Channels (Xiang Q. Gu, Hang Yao, and
Gabriel G. Haddad). 10 In Vivo Roles of Ion Channel Regulatory Protein
Complexes in Neuronal Physiology and Behavior (Smitha Reddy, Mohammad
Shahidullah, and Irwin B. Levitan). 11 Regulation of Neuronal Ion Channels
by G-Protein-Coupled Receptors in Sympathetic Neurons (Mark S. Shapiro and
Nikita Gamper). 12 BK Channels: Regulation of Expression and Physiological
Impact (P. Kundu, A. Alioua, Y. Kumar, R. Lu, J. Ou, E. Sanchez-Pastor, M.
Li, E. Stefani, and L. Toro). 13 Structural Basis for Auxiliary KChIP
Modulation of Kv4 Channels (KeWei Wang and Jijie Chai). PART 3 DRUG
DISCOVERY TARGETS AND TECHNOLOGY. 14 Sodium Channel Blockers for the
Treatment of Chronic Pain (Mark R. Bowlby and Edward Kaftan). 15 Neuronal
Kv7 Potassium Channels as Emerging Targets for the Treatment of Pain
(Steven I. Dworetzky and Valentin K. Gribkoff). 16 Small-Molecule
Modulators of Large-Conductance, Calcium-Activated (BK) Channels (John E.
Starrett Jr.). 17 High-Throughput Screening Technologies in Ion Channel
Drug Discovery (Edward B. Stevens, Andrew D. Whyment, and J. Mark
Treherne). Index.
1 Neuronal L-Type Voltage-Gated Calcium Channels (Alexander Scriabine and
David J. Triggle). 2 Voltage-Gated N-Type and T-Type Calcium Channels and
Excitability Disorders (Elizabeth Tringham and Terrance P. Snutch). 3
Voltage-Gated Sodium Channels: Multiple Roles in the Pathophysiology of
Pain (Sulayman D. Dib-Hajj, Bryan C. Hains, Joel A. Black, and Stephen G.
Waxman). 4 The Role of Ion Channels in the Etiology and Development of
Gliomas (Amy K. Weaver and Harald Sontheimer). 5 Shaker Family Kv1
Voltage-Gated Potassium Channels in Mammalian Brain Neurons (Helene Vacher
and James S. Trimmer). 6 Unique Mitochondrial Ion Channels: Roles in
Synaptic Transmission and Programmed Cell Death (Elizabeth A. Jonas). 7
Regulation of Neuronal Excitability by the Sodium-Activated Potassium
Channels Slick (SLO2.1) and Slack (SLO2.2) (Valentin K. Gribkoff and
Leonard K. Kaczmarek). PART 2 MODULATORY MECHANISMS AND INFLUENCES ON
NEURONAL VOLTAGE-GATED ION CHANNEL FUNCTION. 8 Alternative Splicing of
Neuronal Cav2 Calcium Channels (Diane Lipscombe, Summer E. Allen, Annette
C. Gray, Spiro Marangoudakis, and Jesica Raingo). 9 Effect of
Hypoxia/Ischemia on Voltage-Dependent Channels (Xiang Q. Gu, Hang Yao, and
Gabriel G. Haddad). 10 In Vivo Roles of Ion Channel Regulatory Protein
Complexes in Neuronal Physiology and Behavior (Smitha Reddy, Mohammad
Shahidullah, and Irwin B. Levitan). 11 Regulation of Neuronal Ion Channels
by G-Protein-Coupled Receptors in Sympathetic Neurons (Mark S. Shapiro and
Nikita Gamper). 12 BK Channels: Regulation of Expression and Physiological
Impact (P. Kundu, A. Alioua, Y. Kumar, R. Lu, J. Ou, E. Sanchez-Pastor, M.
Li, E. Stefani, and L. Toro). 13 Structural Basis for Auxiliary KChIP
Modulation of Kv4 Channels (KeWei Wang and Jijie Chai). PART 3 DRUG
DISCOVERY TARGETS AND TECHNOLOGY. 14 Sodium Channel Blockers for the
Treatment of Chronic Pain (Mark R. Bowlby and Edward Kaftan). 15 Neuronal
Kv7 Potassium Channels as Emerging Targets for the Treatment of Pain
(Steven I. Dworetzky and Valentin K. Gribkoff). 16 Small-Molecule
Modulators of Large-Conductance, Calcium-Activated (BK) Channels (John E.
Starrett Jr.). 17 High-Throughput Screening Technologies in Ion Channel
Drug Discovery (Edward B. Stevens, Andrew D. Whyment, and J. Mark
Treherne). Index.