Biphenyl derivatives have been found to be very effective against many therapeutic diseases. It is found to be an effective non-steroidal anti-inflammatory drug. The chemist and biologist describe their various properties, such as- anti-inflammatory, analgesic, anti-pyretic, anti-HIV, anti-malarial, anti-cancer, anti-tumor, anti-microbial and many Others.This book introduce a relatively new approach for the synthesis of biphenyl derivatives inappropriate time and by using simple techniques. The derivatives that synthesized employed for the antifungal properties against two fungi named Fusarium udum and Curvalaria lunata.