Studies on Naturally Occurring and Synthetic Quinones - Pokharna, C. P.
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Many synthetic as well as natural products containing the quinone functionality have displayed useful chemotherapeutic activity. Benzoyl/naphthoyl/thienoyl-1,4-benzoquinones have emerged as potential building blocks for the synthesis of medicinally significant anthracyclinones. Anthracyclinones are valuable drugs in the treatment of certain human cancers. The 1,4-benzoquinones are strong electrophiles in the Diels-Alder reactions with variously substituted 1,3-butadienes. This property of quinones has been of great synthetic value.Encouraged by remarkable achievements in the field of naturally…mehr

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Produktbeschreibung
Many synthetic as well as natural products containing the quinone functionality have displayed useful chemotherapeutic activity. Benzoyl/naphthoyl/thienoyl-1,4-benzoquinones have emerged as potential building blocks for the synthesis of medicinally significant anthracyclinones. Anthracyclinones are valuable drugs in the treatment of certain human cancers. The 1,4-benzoquinones are strong electrophiles in the Diels-Alder reactions with variously substituted 1,3-butadienes. This property of quinones has been of great synthetic value.Encouraged by remarkable achievements in the field of naturally occurring as well as synthetic quinones , a systematic study of quinones including their isolation and synthesis have been undertaken. In the present study isolation of quinones from Tecomellaundulata, synthesis of rhinacanthin-A (a naphthoquinone) from lapachol and a number of benzoyl-1,4-benzoquinones were synthesized which are good precursors for the Diels-Alder reaction with various dienes and therefore, this approach may further be extended to the synthesis of anthracyclinones.
Autorenporträt
Dr. C. P. Pokharna is Associate Professor and Head, Department of Chemistry, S.R.K.P. Government P.G. College, Kishangarh, Ajmer(India). He obtained his Ph.D. from the University of Rajasthan, India. He has an experience of around 25 years of teaching. Dr. Pokharna has presented his research work in about 29 national and international confeerences.