Study of the Genotoxic effect of drugs induced genetic damage in mice - Veerabathiran, Ramakrishnan
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The micronucleus test (MNT) on mammalian bone marrow is widely accepted as a toxicological screening test used as a sensitive method for measuring genetic damage. The aim of the current study was to evaluate frequency of micronucleated polychromatic erythrocytes in the bone marrow of mice treated with 2-Deoxy -D- Glucose (2DG) and cyclophosphamide (CPH). The mean MnPCE values are found a significant inhibition in micronuclei formation was noticed with Cyclophosphamide 125 mg/kg body weight dose (p 0.001) to compare with 2 DG and control groups. When we use 2-DG in the MN analysis, it was…mehr

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Produktbeschreibung
The micronucleus test (MNT) on mammalian bone marrow is widely accepted as a toxicological screening test used as a sensitive method for measuring genetic damage. The aim of the current study was to evaluate frequency of micronucleated polychromatic erythrocytes in the bone marrow of mice treated with 2-Deoxy -D- Glucose (2DG) and cyclophosphamide (CPH). The mean MnPCE values are found a significant inhibition in micronuclei formation was noticed with Cyclophosphamide 125 mg/kg body weight dose (p 0.001) to compare with 2 DG and control groups. When we use 2-DG in the MN analysis, it was observed that the 0.5 mg/kg MnPCE level was higher in treated mice as compared to controls. The 1.0 mg/kg MnPCE level was lower. The 2.0 mg/kg MnPCE level also was lower however; the differences were highly significant (p 0.001). The combination of Cyclophosphamide and 2-Deoxy -D- Glucose 0.5 mg/kg MnPCE level were significantly increased and 1 mg/kg body weight was significantly decreased, overall the combination results were showing (p 0.001). This study revealed that mice MN assay can be used as a genotoxicological test-system since some methodological particularities were observed.
Autorenporträt
Both the authors are Assistant Professor at Chettinad Academy of Research and Education Chennai. The authors are potentially involved in research areas are Molecular Cytogenetics and System Biology.