Study on in vitro/in vivo correlation of pyridostigmine bromide - Huang, Yuh-Tyng
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Pyridostigmine bromide (PB), a highly hygroscopic drug was selected as the model drug. The PB sustained-release (SR) dosage forms that were developed by extrusion-spheronization, direct compression and fluid-bed methods. Produced by the aforementioned methods, the optimal PB-SR dosage forms could improve the hygroscopic defect of PB and reach the SR effect. In vivo study, a good linear regression relationship was observed between the fraction dissolution and fraction absorption for the optimal PB-SR dosage forms. However, the results of microdialysis technique shown that the release of…mehr

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Produktbeschreibung
Pyridostigmine bromide (PB), a highly hygroscopic drug was selected as the model drug. The PB sustained-release (SR) dosage forms that were developed by extrusion-spheronization, direct compression and fluid-bed methods. Produced by the aforementioned methods, the optimal PB-SR dosage forms could improve the hygroscopic defect of PB and reach the SR effect. In vivo study, a good linear regression relationship was observed between the fraction dissolution and fraction absorption for the optimal PB-SR dosage forms. However, the results of microdialysis technique shown that the release of acetylcholine and the release of protein unbound drug for the PB-SR pellets provided with SR effect in vivo as well.
Autorenporträt
The book's author is Dr. Yuh-Tyng Huang. She graduated from Kaohsiung Medical University in Taiwan. In academic fields, she major in ¿pharmaceutical dosage forms design¿ and "pharmacokinetics". Currently, she is an assistant professor of Chung Hwa University of Medical Technology in Taiwan.