God created human species with beauty and precision. However, man brought himself closer to his own doom with the inadvertent use of illicit substances. Substance abuse has been known to be one of the most common problem of present times. The best way to stop abuse is to never start. It has been observed that early diagnosis and treatment leads a better prognosis. Therefore, dental professionals are in an excellent position for early detection and treatment of such conditions. The book provides an insight into the oral and systemic manifestations of various drug abuse. Also, it provides a comprehensive prevention and treatment strategy for its control.