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Aim of this work is to observe some interesting phenomena involving pre and post pandemia cardiac sudden deaths epidemiology and after the mass vaccination campaign.The current level of unexpected extradeaths as reported in scientific literature vs prepandemic years.So it is need a deeply investigation in order to verify association or not with Spike protein derivates used .Of interest to observe the prevalence/ incidence of cardiac sudden deaths after covid-19 disease before the vaccination seasons.This review is performed whit a neutral approach and without pre - conceptAll data comes from biomedical database and published as article .