Sulfonated Derivatives of 2,4-Xylidine: Possible Therapeutic Agents - Abbasi, Muhammad Athar;Siddiqui, Sabahat Zahra
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Sulfonamides are considered to be pharmaceutically important class of compounds. In the present work, N-(2,4-dimethylphenyl)-4-toluenesulfonamide was synthesized by the reaction of 2,4-dimethylaniline and 4-tosyl chloride (4-methylbenzenesulfonyl chloride) using 10% aqueous Na2CO3 solution as reaction medium. At the second step, the synthesized molecule was made to react with different alkyl/aralkyl halides to yield the target compounds,using N,N-dimethylformamide (DMF) as reaction medium and lithium hydride as an activator. The synthesis of all the compounds was verified by spectral…mehr

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Produktbeschreibung
Sulfonamides are considered to be pharmaceutically important class of compounds. In the present work, N-(2,4-dimethylphenyl)-4-toluenesulfonamide was synthesized by the reaction of 2,4-dimethylaniline and 4-tosyl chloride (4-methylbenzenesulfonyl chloride) using 10% aqueous Na2CO3 solution as reaction medium. At the second step, the synthesized molecule was made to react with different alkyl/aralkyl halides to yield the target compounds,using N,N-dimethylformamide (DMF) as reaction medium and lithium hydride as an activator. The synthesis of all the compounds was verified by spectral techniques using IR, 1H-NMR and EIMS; and further examined for their anti-enzymatic activities. The synthesized compounds represented the most potential against -glucosidase and lipoxygenase enzymes.
Autorenporträt
Muhammad Athar Abbasi (Assoc. Prof., GCU, Lahore) is HEC approved supervisor. He is a recipient of Research Productivity Award from 2008-14 from PCST, Pakistan. He has authored 141 research papers.Sabahat Zahra Siddiqui (Lecturer, GCU, Lahore) has authored 40 research publications. She worked as a research scholar at University of Pennsylvania.