Tsutomu Ishikawa
Superbases for Organic Synthesis
Guanidines, Amidines, Phosphazenes and Related Organocatalysts
Ed. by Tsutomu Ishikawa
Tsutomu Ishikawa
Superbases for Organic Synthesis
Guanidines, Amidines, Phosphazenes and Related Organocatalysts
Ed. by Tsutomu Ishikawa
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First book dealing with the synthesis and chemistry of the superbases guanidines, amidines and phosphazenes; widely-used tools in preparative organic chemistry. This is a hot topic area because of superbase's chemical properties, potential as catalysts, and derivation from sustainable biomaterial sources. This essential guide includes details of physical properties, biological roles, synthetic applications, appearance and synthesis as natural products, and use in medicinal chemistry.
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First book dealing with the synthesis and chemistry of the superbases guanidines, amidines and phosphazenes; widely-used tools in preparative organic chemistry. This is a hot topic area because of superbase's chemical properties, potential as catalysts, and derivation from sustainable biomaterial sources. This essential guide includes details of physical properties, biological roles, synthetic applications, appearance and synthesis as natural products, and use in medicinal chemistry.
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Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
Produktdetails
- Produktdetails
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 336
- Erscheinungstermin: 2. März 2009
- Englisch
- Abmessung: 249mm x 175mm x 23mm
- Gewicht: 724g
- ISBN-13: 9780470518007
- ISBN-10: 0470518006
- Artikelnr.: 25625757
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- 06621 890
- Verlag: Wiley & Sons
- 1. Auflage
- Seitenzahl: 336
- Erscheinungstermin: 2. März 2009
- Englisch
- Abmessung: 249mm x 175mm x 23mm
- Gewicht: 724g
- ISBN-13: 9780470518007
- ISBN-10: 0470518006
- Artikelnr.: 25625757
- Herstellerkennzeichnung
- Libri GmbH
- Europaallee 1
- 36244 Bad Hersfeld
- 06621 890
Professor Tsutomu Ishikawa, Graduate School of Pharmaceutical Sciences, Chiba University, Japan Professor Ishikawa leads a laboratory of researchers at Chiba University in the fields of drug-oriented organic chemistry, natural product chemistry, guanidine-based organic reactions, synthetic studies on aziridines, and the preparation of new polymer-supported reagents. He has published 30 papers, including "Guanidines in Organic Synthesis" - one of the top 5 most downloaded papers of 2006 in the leading organic chemistry journal Synthesis.
Preface.
Acknowledgements.
List of Contributors.
1. General Aspects of Organosuperbases (Tsutomu Ishikawa).
2. Physicochemical Properties of Organic Superbases (Davor Margetic).
2.1 Introduction.
2.2 Proton sponges.
2.3 Amidines.
2.4 Guanidines.
2.5 Phosphazenes.
2.6 Guanidinophosphazenes.
2.7 Other Phosphorus Containing Superbases: Verkade's Proazaphosphatranes.
2.8 Theoretical Methods.
2.9 Concluding Remarks.
References.
3. Amidines in Organic Synthesis (Tsutomu Ishikawa and Takuya Kumamoto).
3.1 Introduction.
3.2 Preparation of Amidine.
3.3 Application of Amidines to Organic Synthesis.
3.4 Amidinium Salt: Design and Synthesis.
3.5 Concluding Remarks.
References.
4. Guanidines in Organic Synthesis (Tsutomu Ishikawa).
4.1. Introduction.
4.2. Preparation of Chiral Guanidines.
4.3 Guanidines as Synthetic Tools.
4.4 Guanidinium Salt.
4.5 Concluding Remarks.
References.
5. Phosphazene: Preparation, Reaction and Catalytic Role (Yoshinori Kondo).
5.1 Introduction.
5.2 Deprotonative Transformations Using Stoichiometric Phosphazenes.
5.3 Transformation Using Phosphazene Catalyst.
5.4 Proazaphosphatrane Base (Verkade's Base).
5.5 Concluding Remarks.
References.
6. Polymer-supported Organosuperbases (Hiyoshizo Kotsuki).
6.1 Introduction.
6.2 Acylation reactions.
6.3 Alkylation Reactions.
6.4 Heterocyclization.
6.5 Miscellaneous.
6.6 Concluding Remarks.
References.
7. Application of Organosuperbases to Total Synthesis (Kazuo Nagasawa).
7.1 Introduction.
7.2 Carbon-carbon bond-forming reactions.
7.3 Deprotection.
7.4 Elimination.
7.5 Ether synthesis.
7.6 Heteroatom conjugate addition.
7.7 Isomerization.
7.8 Concluding Remarks.
References.
8. Related Organocatalysts (1): Proton Sponge (Kazuo Nagasawa).
8.1 Introduction.
8.2 Alkylation and Hetero Michael reaction.
8.3 Amide formation.
8.4 Carbon-carbon bond-forming reaction.
8.5 Palladium-catalyzed reaction.
8.6 Concluding Remarks.
References.
9. Related Organocatalysts (2): Urea Derivatives (Waka Nakanishi).
9.1 Introduction.
9.2 Bisphenol as Organoacid Catalyst.
9.3 Urea and Thiourea as Achiral Catalysts.
9.4 Urea and Thiourea as Chiral Catalyst.
9.5 Concluding Remarks.
References.
10. Amidines and Guanidines in Natural Products and Medicines (Takuya
Kumamoto).
10.1 Introduction.
10.2 Natural Amidine Derivatives.
10.3 Natural Guanidine Derivatives.
10.4 Medicinal Amidine and Guanidine Derivatives.
References.
11. Perspective (Tsutomu Ishikawa and Davor Margetic).
Acknowledgements.
List of Contributors.
1. General Aspects of Organosuperbases (Tsutomu Ishikawa).
2. Physicochemical Properties of Organic Superbases (Davor Margetic).
2.1 Introduction.
2.2 Proton sponges.
2.3 Amidines.
2.4 Guanidines.
2.5 Phosphazenes.
2.6 Guanidinophosphazenes.
2.7 Other Phosphorus Containing Superbases: Verkade's Proazaphosphatranes.
2.8 Theoretical Methods.
2.9 Concluding Remarks.
References.
3. Amidines in Organic Synthesis (Tsutomu Ishikawa and Takuya Kumamoto).
3.1 Introduction.
3.2 Preparation of Amidine.
3.3 Application of Amidines to Organic Synthesis.
3.4 Amidinium Salt: Design and Synthesis.
3.5 Concluding Remarks.
References.
4. Guanidines in Organic Synthesis (Tsutomu Ishikawa).
4.1. Introduction.
4.2. Preparation of Chiral Guanidines.
4.3 Guanidines as Synthetic Tools.
4.4 Guanidinium Salt.
4.5 Concluding Remarks.
References.
5. Phosphazene: Preparation, Reaction and Catalytic Role (Yoshinori Kondo).
5.1 Introduction.
5.2 Deprotonative Transformations Using Stoichiometric Phosphazenes.
5.3 Transformation Using Phosphazene Catalyst.
5.4 Proazaphosphatrane Base (Verkade's Base).
5.5 Concluding Remarks.
References.
6. Polymer-supported Organosuperbases (Hiyoshizo Kotsuki).
6.1 Introduction.
6.2 Acylation reactions.
6.3 Alkylation Reactions.
6.4 Heterocyclization.
6.5 Miscellaneous.
6.6 Concluding Remarks.
References.
7. Application of Organosuperbases to Total Synthesis (Kazuo Nagasawa).
7.1 Introduction.
7.2 Carbon-carbon bond-forming reactions.
7.3 Deprotection.
7.4 Elimination.
7.5 Ether synthesis.
7.6 Heteroatom conjugate addition.
7.7 Isomerization.
7.8 Concluding Remarks.
References.
8. Related Organocatalysts (1): Proton Sponge (Kazuo Nagasawa).
8.1 Introduction.
8.2 Alkylation and Hetero Michael reaction.
8.3 Amide formation.
8.4 Carbon-carbon bond-forming reaction.
8.5 Palladium-catalyzed reaction.
8.6 Concluding Remarks.
References.
9. Related Organocatalysts (2): Urea Derivatives (Waka Nakanishi).
9.1 Introduction.
9.2 Bisphenol as Organoacid Catalyst.
9.3 Urea and Thiourea as Achiral Catalysts.
9.4 Urea and Thiourea as Chiral Catalyst.
9.5 Concluding Remarks.
References.
10. Amidines and Guanidines in Natural Products and Medicines (Takuya
Kumamoto).
10.1 Introduction.
10.2 Natural Amidine Derivatives.
10.3 Natural Guanidine Derivatives.
10.4 Medicinal Amidine and Guanidine Derivatives.
References.
11. Perspective (Tsutomu Ishikawa and Davor Margetic).
Preface.
Acknowledgements.
List of Contributors.
1. General Aspects of Organosuperbases (Tsutomu Ishikawa).
2. Physicochemical Properties of Organic Superbases (Davor Margetic).
2.1 Introduction.
2.2 Proton sponges.
2.3 Amidines.
2.4 Guanidines.
2.5 Phosphazenes.
2.6 Guanidinophosphazenes.
2.7 Other Phosphorus Containing Superbases: Verkade's Proazaphosphatranes.
2.8 Theoretical Methods.
2.9 Concluding Remarks.
References.
3. Amidines in Organic Synthesis (Tsutomu Ishikawa and Takuya Kumamoto).
3.1 Introduction.
3.2 Preparation of Amidine.
3.3 Application of Amidines to Organic Synthesis.
3.4 Amidinium Salt: Design and Synthesis.
3.5 Concluding Remarks.
References.
4. Guanidines in Organic Synthesis (Tsutomu Ishikawa).
4.1. Introduction.
4.2. Preparation of Chiral Guanidines.
4.3 Guanidines as Synthetic Tools.
4.4 Guanidinium Salt.
4.5 Concluding Remarks.
References.
5. Phosphazene: Preparation, Reaction and Catalytic Role (Yoshinori Kondo).
5.1 Introduction.
5.2 Deprotonative Transformations Using Stoichiometric Phosphazenes.
5.3 Transformation Using Phosphazene Catalyst.
5.4 Proazaphosphatrane Base (Verkade's Base).
5.5 Concluding Remarks.
References.
6. Polymer-supported Organosuperbases (Hiyoshizo Kotsuki).
6.1 Introduction.
6.2 Acylation reactions.
6.3 Alkylation Reactions.
6.4 Heterocyclization.
6.5 Miscellaneous.
6.6 Concluding Remarks.
References.
7. Application of Organosuperbases to Total Synthesis (Kazuo Nagasawa).
7.1 Introduction.
7.2 Carbon-carbon bond-forming reactions.
7.3 Deprotection.
7.4 Elimination.
7.5 Ether synthesis.
7.6 Heteroatom conjugate addition.
7.7 Isomerization.
7.8 Concluding Remarks.
References.
8. Related Organocatalysts (1): Proton Sponge (Kazuo Nagasawa).
8.1 Introduction.
8.2 Alkylation and Hetero Michael reaction.
8.3 Amide formation.
8.4 Carbon-carbon bond-forming reaction.
8.5 Palladium-catalyzed reaction.
8.6 Concluding Remarks.
References.
9. Related Organocatalysts (2): Urea Derivatives (Waka Nakanishi).
9.1 Introduction.
9.2 Bisphenol as Organoacid Catalyst.
9.3 Urea and Thiourea as Achiral Catalysts.
9.4 Urea and Thiourea as Chiral Catalyst.
9.5 Concluding Remarks.
References.
10. Amidines and Guanidines in Natural Products and Medicines (Takuya
Kumamoto).
10.1 Introduction.
10.2 Natural Amidine Derivatives.
10.3 Natural Guanidine Derivatives.
10.4 Medicinal Amidine and Guanidine Derivatives.
References.
11. Perspective (Tsutomu Ishikawa and Davor Margetic).
Acknowledgements.
List of Contributors.
1. General Aspects of Organosuperbases (Tsutomu Ishikawa).
2. Physicochemical Properties of Organic Superbases (Davor Margetic).
2.1 Introduction.
2.2 Proton sponges.
2.3 Amidines.
2.4 Guanidines.
2.5 Phosphazenes.
2.6 Guanidinophosphazenes.
2.7 Other Phosphorus Containing Superbases: Verkade's Proazaphosphatranes.
2.8 Theoretical Methods.
2.9 Concluding Remarks.
References.
3. Amidines in Organic Synthesis (Tsutomu Ishikawa and Takuya Kumamoto).
3.1 Introduction.
3.2 Preparation of Amidine.
3.3 Application of Amidines to Organic Synthesis.
3.4 Amidinium Salt: Design and Synthesis.
3.5 Concluding Remarks.
References.
4. Guanidines in Organic Synthesis (Tsutomu Ishikawa).
4.1. Introduction.
4.2. Preparation of Chiral Guanidines.
4.3 Guanidines as Synthetic Tools.
4.4 Guanidinium Salt.
4.5 Concluding Remarks.
References.
5. Phosphazene: Preparation, Reaction and Catalytic Role (Yoshinori Kondo).
5.1 Introduction.
5.2 Deprotonative Transformations Using Stoichiometric Phosphazenes.
5.3 Transformation Using Phosphazene Catalyst.
5.4 Proazaphosphatrane Base (Verkade's Base).
5.5 Concluding Remarks.
References.
6. Polymer-supported Organosuperbases (Hiyoshizo Kotsuki).
6.1 Introduction.
6.2 Acylation reactions.
6.3 Alkylation Reactions.
6.4 Heterocyclization.
6.5 Miscellaneous.
6.6 Concluding Remarks.
References.
7. Application of Organosuperbases to Total Synthesis (Kazuo Nagasawa).
7.1 Introduction.
7.2 Carbon-carbon bond-forming reactions.
7.3 Deprotection.
7.4 Elimination.
7.5 Ether synthesis.
7.6 Heteroatom conjugate addition.
7.7 Isomerization.
7.8 Concluding Remarks.
References.
8. Related Organocatalysts (1): Proton Sponge (Kazuo Nagasawa).
8.1 Introduction.
8.2 Alkylation and Hetero Michael reaction.
8.3 Amide formation.
8.4 Carbon-carbon bond-forming reaction.
8.5 Palladium-catalyzed reaction.
8.6 Concluding Remarks.
References.
9. Related Organocatalysts (2): Urea Derivatives (Waka Nakanishi).
9.1 Introduction.
9.2 Bisphenol as Organoacid Catalyst.
9.3 Urea and Thiourea as Achiral Catalysts.
9.4 Urea and Thiourea as Chiral Catalyst.
9.5 Concluding Remarks.
References.
10. Amidines and Guanidines in Natural Products and Medicines (Takuya
Kumamoto).
10.1 Introduction.
10.2 Natural Amidine Derivatives.
10.3 Natural Guanidine Derivatives.
10.4 Medicinal Amidine and Guanidine Derivatives.
References.
11. Perspective (Tsutomu Ishikawa and Davor Margetic).