This book represents the first comprehensive review of the SCN, documenting the modern period of research in this field. It describes the organization of the SCN, its efferent projections and the visual pathways from the retina to the SCN. Four chapters deal with the in vitro and in vivo work on the electrophysiological and biochemical features of intrinsic SCN rhythms. Circadian rhythms driven by the SCN are covered in another set of chapters, which discuss pineal function, melatonin production, temperature regulation, and yearly cycles in reproduction and other functions. The neurochemistry, pharmacology and molecular biology of the SCN are reviewed, and there are several chapters on development and transplantation. There is also a discussion of the human circadian system and the evidence for circadian disorders. Based on a conference sponsored by the National Institutes of Health, this is the most up-to-date and definitive reference work on the suproachiasmatic nucleus and its role in setting biological rhythms.
Table of contents:
I. David C. Klein: Historical perspective; Andreas Oksche: The development of the concept of photoneuroendocrine systems: Historical perspective; II. Anatomy and Physiology: Robert Y. Moore: The suprachiasmatic nucleus and the circadian timing system; Anthony N. van den Pol: The suprachiasmatic nucleus: morphological and cytochemical substrates for cellular interaction; J. Patrick Card & Robert Y. Moore: The organization of visual circuits influencing the circadian activity of the suprachiasmatic nucleus; Alan G. Watts: The efferent projections of the suprachiasmatic nucleus: anatomical insights into the control of circadian rhythms; J.H. Miejer: Integration of visual information by the suprachiasmatic nucleus; III. Intrinsic SCN rhythms: Martha L.U. Gillette: Introduction; Martha L.U. Gillette: Suprachiasmatic nucleus electrophysiology in vitro: Rhythm activity and endogenous clock properties; William G. Schwartz: Suprachiasmatic nucleus metabolic activity in vitro; George G. Newman: Suprachiasmatic nucleus metabolic activity in Vivo; Joseph A. Majzoub: Suprachiasmatic nuclear rhythms of vasopressin mRNA in vivo; IV. Circadian SCN outputs: Fred W. Turek: Introduction: circadian rhythms as outputs from the suprachiasmatic nucleus; Helena Illnerova: The suprachiasmatic nucleus and rhythmic pineal melatonin production; Fred J. Karsch: Melatonin and mammalian photoperiodism: synchronization of annual reproductive cycles; E. Melanie W. Kittrell: The suprachiasmatic nucleus and temperature rhythms; Irving Zucker: The suprachiasmatic nucleus and annual rhythms of mammals; V. Neuropharmacology of the SCN: Martin Katz: Introduction: Neuropharmacology of the suprachiasmatic nucleus; H.E. Albers: Neurochemistry of circadian Timing; David R. Weaver: Localization of melatonin receptors in mammalian brain; Vincent M. Cassone: Melatonin and suprachiasmatic nucleus; Lawrence P. Morin: Neural control of circadian rhythms as revealed through the use of benzodiazapines; VI: SCN transplants: Steven M. Reppert: Introduction; Martin R. Ralph: Suprachiasmatic nucleus transplant studies using the Tau mutation in golden hamsters; Michael N. Lehman: Anatomy of suprachiasmatic nucleus grafts; VII: Development of the SCN: Frederick C. Davis: Introduction: Development of circadian pacemakers; Robert Y. Moore: Development of the suprachiasmatic nucleus; Steven M. Reppert: A biological clock is oscillating in the fetal suprachiasmatic nuclei; Scott A. Rivkees & Steven M. Reppert: Development of SCN anatomy and function in an opossum; Robert Y. Moore: Disorders of circadian function and the human circadian timing system; VIII: Steven M. Reppert: Toward a molecular approach: Neil Aronin, William J. Schwartz: A new strategy to explore molecular mechanisms of suprachiasmatic nucleus function.
The suprachiasmatic nucleus (SCN) is the part of the brain that controls circadian rhythms in mammals; these biological rhythms range form daily fluctuations in metabolism to seasonal and annual cycles. This book presents a comprehensive and incisive review of the SCN. It covers anatomy and physiology, intrinsic SCN rhythms, circadian rhythms, neuropharmacology, transplants and development. Based on a conference funded by the National Institute of Health, this timely book is the most up-to-date and definitive reference on the subject.
Table of contents:
I. David C. Klein: Historical perspective; Andreas Oksche: The development of the concept of photoneuroendocrine systems: Historical perspective; II. Anatomy and Physiology: Robert Y. Moore: The suprachiasmatic nucleus and the circadian timing system; Anthony N. van den Pol: The suprachiasmatic nucleus: morphological and cytochemical substrates for cellular interaction; J. Patrick Card & Robert Y. Moore: The organization of visual circuits influencing the circadian activity of the suprachiasmatic nucleus; Alan G. Watts: The efferent projections of the suprachiasmatic nucleus: anatomical insights into the control of circadian rhythms; J.H. Miejer: Integration of visual information by the suprachiasmatic nucleus; III. Intrinsic SCN rhythms: Martha L.U. Gillette: Introduction; Martha L.U. Gillette: Suprachiasmatic nucleus electrophysiology in vitro: Rhythm activity and endogenous clock properties; William G. Schwartz: Suprachiasmatic nucleus metabolic activity in vitro; George G. Newman: Suprachiasmatic nucleus metabolic activity in Vivo; Joseph A. Majzoub: Suprachiasmatic nuclear rhythms of vasopressin mRNA in vivo; IV. Circadian SCN outputs: Fred W. Turek: Introduction: circadian rhythms as outputs from the suprachiasmatic nucleus; Helena Illnerova: The suprachiasmatic nucleus and rhythmic pineal melatonin production; Fred J. Karsch: Melatonin and mammalian photoperiodism: synchronization of annual reproductive cycles; E. Melanie W. Kittrell: The suprachiasmatic nucleus and temperature rhythms; Irving Zucker: The suprachiasmatic nucleus and annual rhythms of mammals; V. Neuropharmacology of the SCN: Martin Katz: Introduction: Neuropharmacology of the suprachiasmatic nucleus; H.E. Albers: Neurochemistry of circadian Timing; David R. Weaver: Localization of melatonin receptors in mammalian brain; Vincent M. Cassone: Melatonin and suprachiasmatic nucleus; Lawrence P. Morin: Neural control of circadian rhythms as revealed through the use of benzodiazapines; VI: SCN transplants: Steven M. Reppert: Introduction; Martin R. Ralph: Suprachiasmatic nucleus transplant studies using the Tau mutation in golden hamsters; Michael N. Lehman: Anatomy of suprachiasmatic nucleus grafts; VII: Development of the SCN: Frederick C. Davis: Introduction: Development of circadian pacemakers; Robert Y. Moore: Development of the suprachiasmatic nucleus; Steven M. Reppert: A biological clock is oscillating in the fetal suprachiasmatic nuclei; Scott A. Rivkees & Steven M. Reppert: Development of SCN anatomy and function in an opossum; Robert Y. Moore: Disorders of circadian function and the human circadian timing system; VIII: Steven M. Reppert: Toward a molecular approach: Neil Aronin, William J. Schwartz: A new strategy to explore molecular mechanisms of suprachiasmatic nucleus function.
The suprachiasmatic nucleus (SCN) is the part of the brain that controls circadian rhythms in mammals; these biological rhythms range form daily fluctuations in metabolism to seasonal and annual cycles. This book presents a comprehensive and incisive review of the SCN. It covers anatomy and physiology, intrinsic SCN rhythms, circadian rhythms, neuropharmacology, transplants and development. Based on a conference funded by the National Institute of Health, this timely book is the most up-to-date and definitive reference on the subject.