Various methods of polymer surface tailoring have been studied to control the changes in wetting behavior. Polymers having precisely controlled wetting behavior in a specific environment are of great interest in biomaterial engineering. The controlled wetting behavior can be obtained by combining surface chemistry and morphology. Plasma assisted polymer surface modification technique have played a significant part to control surface chemistry and morphology. This book focuses on radio frequency (RF) plasma copolymerization of octafluorocyclobutane and acrylic acid (C4F8-co-AA) and investigations regarding surface chemistry, surface wettability, coating kinetics, as well as coating stability. Main achievements in this book are summarized below. This book has demonstrated a novel approach to fabricate surfaces with tailored wettability by merely controlling plasma polymerization parameters. The controlled wettability can be used to design filters with selective wettability for oil-water separation industry. Moreover, this technique will be helpful to design the pH-responsive biomaterials for tumor-targeted drug delivery.