Both an introduction and a fundamental reference, this book explores how to apply genomic, proteomic, and metabolomic technologies to surrogate tissue analysis. It reviews fundamental analytical issues and actual initial results generated using these technologies. The book covers transcriptional profiling (genomics), protein profiling (proteomics), methylation profiling (epigenomics), metabolite profiling (metabolomics) and additional biomarker identification methods that can be applied to surrogate tissues. This book is useful to researchers and scientists interested in applying novel…mehr
Both an introduction and a fundamental reference, this book explores how to apply genomic, proteomic, and metabolomic technologies to surrogate tissue analysis. It reviews fundamental analytical issues and actual initial results generated using these technologies. The book covers transcriptional profiling (genomics), protein profiling (proteomics), methylation profiling (epigenomics), metabolite profiling (metabolomics) and additional biomarker identification methods that can be applied to surrogate tissues. This book is useful to researchers and scientists interested in applying novel methodologies for identifying biomarkers in the fields of pharmacology, toxicology, and medicine.
INTRODUCTION TO SURROGATE TISSUE ANALYSIS. Introduction to Surrogate Tissue Analysis. GENOMIC APPROACHES. Impact of Sample Handling and Preparation on Gene Signatures as Exemplified for Transcriptome Analysis of Peripheral Blood. Blood Genomic Fingerprints of Brain Diseases. Transcriptional Profiling of Peripheral Blood in Oncology. Blood-Derived Transcriptomic Profiles as a Means to Monitor Levels of Toxicant Exposure and the Effects of Toxicants on Inaccessible Target Tissues. Spermatozoal RNAs as Surrogate Markers of Paternal Exposure. PROTEOMIC APPROACHES. Proteomic Analysis of Surrogate Tissues: Mass Spectrometry-Based Profiling of the Circulatory Proteome for Cancer Detection and Stratification. Lymphocyte Integrins: Potential Surrogate Biomarkers for Evaluation of Endometrial Receptivity. Nipple Aspirate Fluid to Diagnose Breast Cancer and Monitor Response to Treatment. METABOLOMICS AND OTHER APPROACHES. Metabonomics: Metabolic Profiling and Pattern Recognition Analysis of Body Fluids and Tissues for Characterization of Drug Toxicity and Disease Diagnosis. Comprehensive Metabolomic Profiling of Serum and Cerebrospinal Fluid: Understanding Disease, Human Variability, and Toxicity. Lipidomic Analysis of Plasma and Tissues: Lipid-Derived Mediators of Inflammation and Markers of Disease. Molecular Detection and Characterization of Circulating Tumor Cells and Micrometastases in Solid Tumors. Methylation Profiling of Tumor Cells and Tumor DNA in Blood, Urine, and Body Fluids for Cancer Detection and Monitoring. FUTURE CONSIDERATIONS FOR SURROGATE TISSUE PROFILING. Regulatory and Technical Challenges in Incorporating Surrogate Tissue Profiling Strategies into Clinical Development Programs. Considerations in the Economic Assessment of the Value of Molecular Profiling. The Impact and Challenges of Pan-Omic Approaches in Pharmaceutical Discovery and Development. Current and Future Aspects of Surrogate Tissue Analysis. References.
INTRODUCTION TO SURROGATE TISSUE ANALYSIS. Introduction to Surrogate Tissue Analysis. GENOMIC APPROACHES. Impact of Sample Handling and Preparation on Gene Signatures as Exemplified for Transcriptome Analysis of Peripheral Blood. Blood Genomic Fingerprints of Brain Diseases. Transcriptional Profiling of Peripheral Blood in Oncology. Blood-Derived Transcriptomic Profiles as a Means to Monitor Levels of Toxicant Exposure and the Effects of Toxicants on Inaccessible Target Tissues. Spermatozoal RNAs as Surrogate Markers of Paternal Exposure. PROTEOMIC APPROACHES. Proteomic Analysis of Surrogate Tissues: Mass Spectrometry-Based Profiling of the Circulatory Proteome for Cancer Detection and Stratification. Lymphocyte Integrins: Potential Surrogate Biomarkers for Evaluation of Endometrial Receptivity. Nipple Aspirate Fluid to Diagnose Breast Cancer and Monitor Response to Treatment. METABOLOMICS AND OTHER APPROACHES. Metabonomics: Metabolic Profiling and Pattern Recognition Analysis of Body Fluids and Tissues for Characterization of Drug Toxicity and Disease Diagnosis. Comprehensive Metabolomic Profiling of Serum and Cerebrospinal Fluid: Understanding Disease, Human Variability, and Toxicity. Lipidomic Analysis of Plasma and Tissues: Lipid-Derived Mediators of Inflammation and Markers of Disease. Molecular Detection and Characterization of Circulating Tumor Cells and Micrometastases in Solid Tumors. Methylation Profiling of Tumor Cells and Tumor DNA in Blood, Urine, and Body Fluids for Cancer Detection and Monitoring. FUTURE CONSIDERATIONS FOR SURROGATE TISSUE PROFILING. Regulatory and Technical Challenges in Incorporating Surrogate Tissue Profiling Strategies into Clinical Development Programs. Considerations in the Economic Assessment of the Value of Molecular Profiling. The Impact and Challenges of Pan-Omic Approaches in Pharmaceutical Discovery and Development. Current and Future Aspects of Surrogate Tissue Analysis. References.
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