Why is too difficult to follow up sustainable development in our countries, regions or pilot areas? It is ever as incomplete and only taken account a pair of goals. This book show a model of how to do a complete analysis of sustainability in a special area as a Biosphere Reserve. This book have a basic metrics of sustainability as a step for to do analysis in different scales around the World, doing management of data, science and research for decision takers and scientific community. Sustainable development, as the Brundlandt Report statement says, is the requirement to meet the needs of the present without compromising the ability of future generations to meet their own needs; it is the road to do the best advance as humanity of the 21st century. UNESCO's Man and the Biosphere programme, is all about sustainability, in an interdisciplinary approach, and UNESCO biosphere reserves are model regions for sustainable development and we should know how is running, and what we can do for to improve. La Amistad Panama Biosphere Reserve is an outstanding area with beautiful landscape and high biodiversity, but also an area with many poor people that deserve oportunities.