SUSTAINED RELEASE MICROPARTICULATE DELIVERY SYSTEM OF INTERFERON-¿-2B - Gulia, Monika
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The encapsulation mechanism of _rINF- -2b in lipid, carbohydrate and protein based microspheres to achieve high encapsulation efficiency and protein loading capacity. _rINF- -2b is a fragile molecule and encapsulation requires in addition the preservation of their structural integrity and functionality. We estimated that _rINF- -2b-Pt-GMs-15 offered sustained release of protein over two weeks and released 95.01±4.23% of _rINF- -2b. The stability study assessment by gel electrophoresis and circular dichroism confirmed post translation structural integrity of _rINF- -2b in _rINF- -2b-Pt-GMs-15…mehr

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Produktbeschreibung
The encapsulation mechanism of _rINF- -2b in lipid, carbohydrate and protein based microspheres to achieve high encapsulation efficiency and protein loading capacity. _rINF- -2b is a fragile molecule and encapsulation requires in addition the preservation of their structural integrity and functionality. We estimated that _rINF- -2b-Pt-GMs-15 offered sustained release of protein over two weeks and released 95.01±4.23% of _rINF- -2b. The stability study assessment by gel electrophoresis and circular dichroism confirmed post translation structural integrity of _rINF- -2b in _rINF- -2b-Pt-GMs-15 nanoformulation. In vitro therapeutic efficacy testing of optimized formulation further provided compelling evidence with enhanced cytotoxicity and low IC50 in SKOV3 cells. Therefore protamine sulphate coated microspheres may potentially be used for sustained delivery of _rINF- -2b and warrants in depth in vivo study to scale up the technology for clinical intervention.
Autorenporträt
Ms. Monika is expert in the area of nanotechnology-based formulation development for cancer. Currently she is working on development and optimization of topical film for drug delivery through skin. Ms. Monika has immense exposure of varied assignments ranging from teaching, training and research and academic administration.