Actinidic archaea has been related to chronic ophthalmologic disease (type 2 diabetes mellitus with retinopathy, cataract, congestive glaucoma, optic neuritis and optic atrophy). The growth of endosymbiotic actinidic archaea leads to neanderthalisation of the human mind-body system. Neanderthal metabolonomics has been described in chronic ophthalmologic disease especially the Warburg phenotype and hyperdigoxinemia. Digoxin produced by archaeal cholesterol catabolism produces neanderthalisation. Prefrontal cortical atrophy and cerebellar hyperplasia has been related to chronic ophthalmologic disease. This leads on to dysautonomia with sympathetic hyperactivity and parasympathetic neuropathy in chronic ophthalmologic disease. A method to modulate archaeal symbiosis and interconverting homo sapien to homo neanderthalis and vice versa is described. This is done by a high fibre versus a low fibre diet, administration of antioxidant antibiotic and colonic microflora from human and cow dung. This can be called as a therapeutic archaeal symbiotic modulated human evolution for the treatment of chronic ophthalmologic disease.