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The treatment of microbial infection is still one of the major problems worldwide due to increased prevalence of microbial resistance and emergence of new infectious diseases. The major factors responsible for increased antimicrobial resistance are irrational and long term use of high dose of antibiotics. The resistance of pathogenic microorganisms toward currently available antimicrobial drugs is the major problem in the world. It possesses a significant threat & may lead to treatment failure and complications. The development of novel and potent antimicrobial agent is a challenging and demanding task for the chemists and pharmacists. Hence an extensive research is going on in this field to overcome the problem of antimicrobial drug resistance. A number of derivatives of various heterocyclic or other compounds had been synthesized in search of novel, potent, effective and less toxic antimicrobial agents. Benzimidazole is a versatile pharmacophore in the field of medicinal chemistry and has adverse range of pharmacological activities. The synthesis of novel benzimidazole derivatives remains a main focus of medicinal research, and provide the vital information for drug discovery.