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The placenta is an essential organ for maintaining pregnancy and fetal growth. Recent studies have demonstrated active microvesicular secretion in the placenta, including exosomes. The incorporation of syncytin-2 on the surface of these exosomes has been clearly demonstrated. The overall aim of our research study is to evaluate syncytin-2 incorporation in exosomes from normal pregnant women between 01 and 20 SA. To this end, serum samples from 173 pregnant women were collected from the beginning of pregnancy to 20 SA. After analyzing the exosome content of these pregnant women, we found a progressive incorporation of syncytin-2 between 0-10 SA, followed by a decrease and stabilization between 16-20 SA. This work could be of interest to students, researchers, professionals, biologists, PhD biologists, doctors and clinicians in the healthcare field, and will generate a great deal of research interest in the years to come.