The heritage of the term syndrome is ancient. Accurate diagnosis of a specific syndromes among the 0.7% of babies born with multiple malformations is a necessary pre requisite of providing a prognosis and plan of management for the affected infant, as well as genetic counseling for the parents.More than 3,000 syndromes classified. Optimal growth, development, and learning requires early recognition and intervention.The purpose of this book is to have an insight into the intricacy of different syndromes of orofacial region, which will help for accurate syndromal diagnosis allows a rational approach to treatment & better prognosis.