Syntheis and characterization of some 2-benzoxazolone derivatives
Abdullahi Garba Usman
Broschiertes Buch

Syntheis and characterization of some 2-benzoxazolone derivatives

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According to the literature, 2-(3H)-benzoxazolone and its derivatives are compounds having different pharmacological activities more especially analgesic and anti-inflammatory. Its ability for modification at different positions makes it be of great interest in medicinal and pharmaceutical chemistry. Consequently they can be used in the development of new drug candidates that are COX-2 selective with less side effects. In this research we synthesized two compounds, Compound 1 via Mannich reaction, under reflux condition which involves modification of the 3rd position of 2-(3H)-benzoxazolone. C...