Synthesis & Biological Evaluation Of Phthalazinone & Pyridazinone - Chandrakanth, Bandapally;Sastry, Girija
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The Pthalazinone and Pyridazinone synthesized by refluxing the mixture of appropriate acid and hydrazine in absolute alcohol and new pyridazinones were also prepared. The intermediate 1,4 ketoacids (beta-aroylpropionic acids) required for the synthesis of Pthalazinone and Pyridazinone (PH-1 to PH-12) were prepared by substituted aromatic compounds with appropriate acid anhydride and All the synthesized compounds were purified by chromatographic and crystallization methods and then identified by physical and their spectral characterization by means of IR, 1H NMR and 13C NMR and Resulted…mehr

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Produktbeschreibung
The Pthalazinone and Pyridazinone synthesized by refluxing the mixture of appropriate acid and hydrazine in absolute alcohol and new pyridazinones were also prepared. The intermediate 1,4 ketoacids (beta-aroylpropionic acids) required for the synthesis of Pthalazinone and Pyridazinone (PH-1 to PH-12) were prepared by substituted aromatic compounds with appropriate acid anhydride and All the synthesized compounds were purified by chromatographic and crystallization methods and then identified by physical and their spectral characterization by means of IR, 1H NMR and 13C NMR and Resulted compounds, were having biological and pharmacological importance like antimicrobial, antifungal, anti-inflammatory activity and in-vitro anti-cancer activity.
Autorenporträt
Research in the field hetero cycle compounds & Analytical chemistry and various drug delivery systems and published 36 international & 4 national journals & visited 2 universities in U.S.A.Attended various international & national conferences.Working as principal of Aurobindo college of pharmaceutical sciences.Guided 42 PG students & 1 Ph.D Fellow.