Synthesis & biological investigation of fluorinated amino acid analogs
Novel Amino Acid-Based Molecules and Their Fluorinated Derivatives That May Bind Specifically To the ¿5/¿1 Integrin
Versandkostenfrei!
Versandfertig in 6-10 Tagen
32,99 €
inkl. MwSt.
PAYBACK Punkte
16 °P sammeln!
Integrins are cell surface receptors that take part in cell cell adhesion and cell extracellular matrix (ECM) adhesion events as well as in cell migration and cell signaling. 5 1 integrins are expressed on a wide range among brain tumor cells. In this study, an intermediate spiroisoxazolinopyrrole of the most specific 5 1 integrin antagonist SJ749 was synthesized. Fischer esterification reaction, Swern oxidation, and Wittig olefination were performed. Next, fluorinated diaminopropionate molecules were synthesized for coupling to SJ749 instead of the (2,4,6-trimethylphenyl) diaminopropionate. F...
Integrins are cell surface receptors that take part in cell cell adhesion and cell extracellular matrix (ECM) adhesion events as well as in cell migration and cell signaling. 5 1 integrins are expressed on a wide range among brain tumor cells. In this study, an intermediate spiroisoxazolinopyrrole of the most specific 5 1 integrin antagonist SJ749 was synthesized. Fischer esterification reaction, Swern oxidation, and Wittig olefination were performed. Next, fluorinated diaminopropionate molecules were synthesized for coupling to SJ749 instead of the (2,4,6-trimethylphenyl) diaminopropionate. Finally, the biological evaluation of the molecules synthesized was performed. These assays included cytotoxicity and cell proliferation.
Andere Kunden interessierten sich für
