The work to be presented in this book entitled "Synthesis, Spectral Characterization and Antifungal Activity of Imidazo Pyridine Derivatives" is divided into Two sections which can be summarised as under. Chapter-1,6 deals with the properties and history of imidazopyridine; Chapter-2,7 covers Experimental section with procedure and spectral data of synthetic imidazopyridine derivatives ; Chapter-3,8 gives the Therapeutic index with microbiological activity and physical data of each compounds ; Chapter-4,9 Spectral data like Mass IR & NMR with spectra ; Chapter-5,10 cover the all references .'No sober Endeavour in life is totally consummate by oneself '. This book work is no exception. The achievement of this project was aided by the assistance of a number of researchers. First and foremost we obeisance before the almighty God for showering his blessing on us and giving us the strength to carry out the present work with utmost commitment and eagerness. We express our sincere thanks to our respected parents, family members and friends for their constant support, stimulation and persistent efforts for completion of this book.