One of the most interesting feature of organic frame work or crystal growth is proton conducting pathway within the ionic channels. Crystal growth is the major stage of crystallization process. The growth method is important because it suggest the impurity and other defect concentration. Among the various methods slow evaporation method is keen interest due to low temperature solution growth. So, the organic base such as benzimidazole is quite interesting compound for crystal growth because it has a property tendency to accept the proton. Due to this property it readily undergoes protanation while it combines with carboxylic acid. Benzimidazole ring displays an important pharmacophor in drug discovery. So, we were investigating the anti-microbial activities of benzimidazolium salicylate crystals.