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Pyrimidine is a well known hetero-cyclic compound, which has been subjected to a large variety of structural modification in order to synthesize derivatives with different biological properties. Pyrimidine derivatives have been reported to possess a broad spectrum of pharmacological properties. Pyrimidine is the most important member of all the diazines as this ring system occurs widely in living organisms. Purines, uric acid, barbituric acid and some anti-malarial and anti-bacterial agents also contain the pyrimidine ring.