Synthesis and Evaluation of Novel Carbazole Derivatives - Tiwari, Archita;Gupta, Sujeet;Mishra, Bharat
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A novel series of substituted carbazole derivatives was synthesized. In the first step, 2-Chloro-9-H-carbazole-3-carbaldehyde formed via vielsmeier-Hack reaction in the presence of DMF and POCl3. The intermediate product formed with the help of the vielsmeier reaction is further treated with a different substituted amine to get a novel carbazole derivative fused with the substituted amine. The structure of substituted carbazole derivative was identified by thin layer chromatography, FT-IR, and 1H NMR. With the help of the maximal electroshock model (MES), the potency of synthesized compounds…mehr

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Produktbeschreibung
A novel series of substituted carbazole derivatives was synthesized. In the first step, 2-Chloro-9-H-carbazole-3-carbaldehyde formed via vielsmeier-Hack reaction in the presence of DMF and POCl3. The intermediate product formed with the help of the vielsmeier reaction is further treated with a different substituted amine to get a novel carbazole derivative fused with the substituted amine. The structure of substituted carbazole derivative was identified by thin layer chromatography, FT-IR, and 1H NMR. With the help of the maximal electroshock model (MES), the potency of synthesized compounds was determined based on their reduction of convulsions at different time intervals. Among all the synthesized compounds, compound 4e showed the maximal anticonvulsant activity. Compound 4c and compound 4f also showed better anticonvulsant activity.
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Autorenporträt
Archita Tiwari have graduated from the background of pharmaceutical chemistry with the degree of Master in Pharmacy ( pharmaceutical chemistry) from BBDNIIT & HIPER Lucknow, India. She is currently working as Assistant Professor at KMCLU, LKO. She has a deep research interest in the field of synthetic, analytical chemistry and impurity testing.