5methyl substituted phenol benzoxazoles derivatives were synthesized by the reaction of 5 methyl 2 amino phenol with various aldehydes in the presence of Ethyl alcohol and lead tetra acetate.all the compounds were characterized by their analytical and spectral data (IR,1HNMR and Mass). synthesized compounds have been evaluated for their antimicrobial and antifungal activities by gram + and gram - and C. Albicans benzoxazoles derivatives shown significant activity as compared to Griseofulvin standard drugs.