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Benzoxazole is an essential building block in organic synthesis which shows various biological activities. A number of methods have been reported for the synthesis of benzoxazole derivatives including the condensation reaction of carboxylic acids, esters, acid chlorides, amides, and aldehydes with o-substituted amino aromatic derivatives. Synthesis of benzoxazole derivatives also synthesised from Carbon disulfide & xanthate compounds, isothiocynate, cyanide, Schiff base and microwave assisted methods.