Synthesis of Branched Amino Polyols and Amino Hydroxy Acids - Bathich, Yaser
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The main aim of this work is the development of synthetic routes towards amino alcohols as well as branched - and beta-amino acids starting from achiral and chiral (racemic and optically active) isoxazolines and N-methylisoxazolinium salts. The isoxazolines were treated with a variety of Grignard reagents and organolithium complexes as C-nucleophiles. These results were comparable to the findings of analog additions to the ''activated'' isoxazolines, that is, to the isoxazolinium salts. The latter react smoothly with Grignard reagents, as well as with weaker C-nucleophiles such as sodium…mehr

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Produktbeschreibung
The main aim of this work is the development of synthetic routes towards amino alcohols as well as branched - and beta-amino acids starting from achiral and chiral (racemic and optically active) isoxazolines and N-methylisoxazolinium salts. The isoxazolines were treated with a variety of Grignard reagents and organolithium complexes as C-nucleophiles. These results were comparable to the findings of analog additions to the ''activated'' isoxazolines, that is, to the isoxazolinium salts. The latter react smoothly with Grignard reagents, as well as with weaker C-nucleophiles such as sodium diethyl malonate or lithium ester enolate. At the same time it was observed, that the addition proceeds with -particly- good diastereoselectivity under mild reaction conditions, leading to good yields of the corresponding substituted isoxazolidines.
Autorenporträt
Dr. Yaser Bathich is an assistant professor at College of Public Health and Informatics - Qassim University, Saudi Arabia.PhD in Organic Chemistry: Institute of Organic Chemistry, Stuttgart University, Germany, Mar. 2006M.Sc. in Chemistry: Al al-Bayt University, Jordan, June 2001B.Sc. in Chemistry: Al al-Bayt University, Jordan, June 1999