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My book consists of three chapter first chaper Introduction which include the following items: A- Chemistry of -lactams i- Methods of preparation ii- Reactivity of -Lactams B- Synthesis of Thiazolidinone. C- Synthesis of Pyrimidine. D- Synthesis of Pyrazole E- Synthesis of Quinone Compounds. F- Synthesis of Thiazoles. G- Heterocyclic analogous of cyclopropane. H- Heterocyclic analogous of cyclobutane. I- Heterocyclic analogous of cyclopentadiene Second chapter include 1- Biological Activity of -lactams 2- Biological Activity ofThiazoles Biological Activity ofquinones and pyrazoles. Third chapter include references