Andere Kunden interessierten sich auch für
![Pyridine Analogues As An Anticancer Agents]( "Pyridine Analogues As An Anticancer Agents")
Pyridine Analogues As An Anticancer Agents23,99 €![Role of curcumin and its analogues in various diseases]( "Role of curcumin and its analogues in various diseases")
Role of curcumin and its analogues in various diseases26,99 €![Synthesis of Curcumin Analogues as Novel Anti Malarial Agents]( "Synthesis of Curcumin Analogues as Novel Anti Malarial Agents")
Synthesis of Curcumin Analogues as Novel Anti Malarial Agents26,99 €![Studies on the Synthesis & Characterization of Mangiferin Analogues]( "Studies on the Synthesis & Characterization of Mangiferin Analogues")
Studies on the Synthesis & Characterization of Mangiferin Analogues36,99 €![Design and Synthesis of New Thiazole Derivatives as Anticancer Agents]( "Design and Synthesis of New Thiazole Derivatives as Anticancer Agents")
Design and Synthesis of New Thiazole Derivatives as Anticancer Agents40,99 €![Structure Activity Relationship of Drugs of Abuse]( "Structure Activity Relationship of Drugs of Abuse")
Structure Activity Relationship of Drugs of Abuse53,99 €![Medicinal Chemistry of 1,3,4-Thiadiazole]( "Medicinal Chemistry of 1,3,4-Thiadiazole")
Medicinal Chemistry of 1,3,4-Thiadiazole23,99 €
In the present study we have reported the synthesis of some new tamoxifen analogues comprising triphenylethylene core moiety which is the pharmacophoric requirement for estrogen receptor to act as anticancer agent by selective estrogen receptor modulation (SERM). Tamoxifen used for both purpose prevention and treatment of estrogen positive breast cancer. According to these knowledges we designed and synthesized new tamoxifen analogues as potential anticancer agents. New tamoxifen analogues contain triphenylethylene skeleton which is connected to 1,3,4-thiadiazole. Most of literature we found 1,3,4-thiadiazole showed good anticancer activity. To know the best structural requirement, we studied docking in which we found high docking score and similar kind of interaction for our designed tamoxifen analogues as compare to tamoxifen.