Synthesis Of Novel Anti-inflammatory Agents With Good Gastric Profiles - Hefny, Ahmed
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Inflammation is a worldwide distributing disease, annoying a lot of people so it is necessary to discover drugs that are capable of eliminating this disease. This dissertation concerned with synthesis of novel indole derivatives as indomethacin analogues. As we Know indomethacin is one of the most potent anti-inflammatory agents but with high gastric toxicity due to its non selective inhibition of both COX isozymes. So, we decided to synthesize these compounds which characterized by high potency and great safety gastric profiles.

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Produktbeschreibung
Inflammation is a worldwide distributing disease, annoying a lot of people so it is necessary to discover drugs that are capable of eliminating this disease. This dissertation concerned with synthesis of novel indole derivatives as indomethacin analogues. As we Know indomethacin is one of the most potent anti-inflammatory agents but with high gastric toxicity due to its non selective inhibition of both COX isozymes. So, we decided to synthesize these compounds which characterized by high potency and great safety gastric profiles.
Autorenporträt
Ahmed Hefny ist Assistenzprofessor an der Abteilung für Medizinische Chemie der Fakultät für Pharmazie der Beni-Suef-Universität. Er schloss sein Studium 2012 ab und beendete seine Masterarbeit 2017. Seine Leidenschaft gilt der chemischen Synthese organischer Verbindungen, der Modifizierung neuartiger Verbindungen aus bestehenden Verbindungen und allen Fragen im Zusammenhang mit der Chemie.