Synthesis of Some Dihydropyrimidinones and Pharmacological Activity - Choudhury, Tirthankar
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This research revealed that the numbers of available heterocyclic compounds are mainly focused on nitrogen-containing compounds, such as quinazolines, indoles, benzimidazole, quinoxalines, coumarins, and pyrimidines, etc. A mixture of substituted aldehydes (0.01 mol) like acetylacetone (method 1) or ethyl acetoacetate (method 2), urea or thiourea (0.01 mol) and lemon juice (0.5 ml) were taken into a round bottom flask and reflux for 1 hour under continuous stirring. After completion of the reaction, the final product was recrystallized for purification. Simultaneously toxicity and…mehr

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Produktbeschreibung
This research revealed that the numbers of available heterocyclic compounds are mainly focused on nitrogen-containing compounds, such as quinazolines, indoles, benzimidazole, quinoxalines, coumarins, and pyrimidines, etc. A mixture of substituted aldehydes (0.01 mol) like acetylacetone (method 1) or ethyl acetoacetate (method 2), urea or thiourea (0.01 mol) and lemon juice (0.5 ml) were taken into a round bottom flask and reflux for 1 hour under continuous stirring. After completion of the reaction, the final product was recrystallized for purification. Simultaneously toxicity and anti-inflammatory activity were performed. But in case of using ethyl acetoacetate in method 2, the percentage yield was more as compared to using acetylacetone in method 1. So the derivatives obtained from method 2 were selected for further toxicity and anti-inflammatory activities.
Autorenporträt
Dr. (Prof.) Tirthankar Choudhury had his M. Pharm (Pharm. Chemistry) in 2008 and Ph.D.(Pharmaceutical Science) in 2012. Till now he had 11 years of teaching experience along with several paper publications. Now he is associated with Editorial and Advisory Boards of many journals.Hoping towards his wide acceptance in Pharmacy profession.