Husam Khalaf, Dheefaf Hassan, Zainab Hassan

SYNTHESIS OF SOME NEW IMIDAZOLE DERIVATIVES VIA SCHIFF BASES

• Broschiertes Buch

Produktbeschreibung

This book involves synthesis of a number of imidazole derivatives starting with Schiff bases. N-benzylidineareneamines (I) synthesized by condensation of primary aromatic amines with aromatic aldehydes in boiling ethanol. Benzene sulfonyl chloride reacts with these Schiff bases in dry benzene to give N-( -chloridbenzyl) benzene sulfonanilides (II). The later undergo a nucleophilic substitution reaction with thiourea in basic medium to give the corresponding iso-thiourea derivatives: -[N-aryl-N-benzenesulfonyl] aminobenzyl-iso-thiourease(III). These iso-thioureas(III) are condensed with bezoin in DMF to offer imidazole derivatives: -[N-aryl-N-benzenesulfonyl] aminobenzyl-2-thio-4,5diphenyl imidazole (IV).Some imidazole derivatives have anti-inflammatory, anti-arthritic, anti-allergic and immune stimulating activity; therefore, we hope that our prepared compounds may have biological activity.

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Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 72
• Erscheinungstermin: 1. September 2021
• Englisch
• Abmessung: 220mm x 150mm x 5mm
• Gewicht: 125g
• ISBN-13: 9786204201443
• ISBN-10: 6204201441
• Artikelnr.: 62707620

Autorenporträt

Husam S. Khalaf, PhD, and M.Sc. of Analytical Chemistry from University of Baghdad, Iraq. B.Sc. of Chemistry from the University of Baghdad, Iraq. He is currently an Assistant Professor Doctor of Analytical Chemistry at the University of Baghdad, Baghdad, Iraq.