The present work involves the synthesis of some new heterocyclic compounds derived from saccharin salt as a starting material. This work wasdivided into four parts. Part One: This part includes synthesis of N-propergel saccharine alkyl azides, 1,2,3-triazole derivatives, and hydrolysis of 1,2,3-triazoles. Part Two: this part include synthesis of new heterocyclic derivatives of Schiff bases, hydrolysis of Schiff bases and chalcone derivatives bearing 1,2,3-triazoles moieties. Part Three: this part include synthesis of new compounds such as: pyrazoline, isoxazoline, pyrimidin-2-one pyrimidin-2-thiol bearing on N-[1-{(p-acetylphenyl)-1,2,3-triazol-4-yl} methyl] saccharin moieties. Part Four: this part includes using some newly synthesized compounds in four different applications.