Synthesis of Sulfonamide by Metal Catalyzed Sulfonamidation
& The Recent Applications in Medicinal Chemistry
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A sulfonamide is the basis of several sulfa drugs. So a lot of work has gone into creating new sulfonamides using metal-free synthesis, which either uses sulfinate salts as intermediates or reacts amino compounds with sulfonyl chlorides. Unfortunately, the processes used to synthesize sulfonyl chlorides-such as oxidative chlorination of organ sulfur and electrophilic aromatic substitution with chlorosulfonic acid-often suffer from severe reaction conditions, a narrow range of applicability. So this book discusses numerous effective techniques such as transition-metals-catalyzed synthesis devel...
A sulfonamide is the basis of several sulfa drugs. So a lot of work has gone into creating new sulfonamides using metal-free synthesis, which either uses sulfinate salts as intermediates or reacts amino compounds with sulfonyl chlorides. Unfortunately, the processes used to synthesize sulfonyl chlorides-such as oxidative chlorination of organ sulfur and electrophilic aromatic substitution with chlorosulfonic acid-often suffer from severe reaction conditions, a narrow range of applicability. So this book discusses numerous effective techniques such as transition-metals-catalyzed synthesis developed for the synthesis of sulfonamide.
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