Synthesis Of Sulphonylhydrazone Agents For The Diagnosis Of Alzheimer

Synthesis Of Sulphonylhydrazone Agents For The Diagnosis Of Alzheimer

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In this work, three new molecules 4-hydroxy salicyaldehyde ethane sulfonylhydrazone (4-OH-salesh), 4-hydroxy salicylaldehyde propane sulfonylhydrazone (4-OH-salpsh) and 4-hydroxy salicylaldehyde butane sulfonylhydrazone (4-OH-salbsh) are synthesized by combining C2H5/C3H7/C4H9 sulfonyl chlorides and hydrazine hydrate and 4-hydroxysalicylaldehyde. The synthesized compounds were characterized by using FT-IR spectroscopic technique. In addition, DFT analyzes of these compounds were performed.Also, three alkyl sulfonylhydrazon series and choline esterase enzymes tested to determine their inhibitio...