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The present study described an efficient and convenient method for the synthesis of thiadiazole derivatives. The incorporation of two different pharamacophores in a single thiadiazole nucleus led to the development of novel derivatives with moderate activity. All the synthesized compounds showed moderate activity against gram +ve & gram -ve bacteria. The screening studies have demonstrated that the newly synthesized compounds exhibit promising antibacterial properties. Therefore, it was concluded that there exists ample scope for further study in this class of compounds.