36,99 €
inkl. MwSt.
Versandkostenfrei*
Versandfertig in 6-10 Tagen
  • Broschiertes Buch

Privileged structures are molecular scaffolds with versatile binding properties, such that a single scaffold is able to provide potent and selective ligands for a range of different biological targets through the simple manipulation of the functional groups. In addition, privileged structures typically exhibit good drug-like properties, which in turn leads to more drug-like compound libraries and leads. In this book the possibility to develop a versatile methodology for the syntheis of biologically relevant privileged scaffolds is deeply explored. The first part of the book is focused on the…mehr

Produktbeschreibung
Privileged structures are molecular scaffolds with versatile binding properties, such that a single scaffold is able to provide potent and selective ligands for a range of different biological targets through the simple manipulation of the functional groups. In addition, privileged structures typically exhibit good drug-like properties, which in turn leads to more drug-like compound libraries and leads. In this book the possibility to develop a versatile methodology for the syntheis of biologically relevant privileged scaffolds is deeply explored. The first part of the book is focused on the development of a multicomponent approach for the synthesis of Dihydropirans and Sugars. The second part of the book is focused on the synthesis and the biological evaluation, against HIV virus, of derivatives with a rhodaninc structure. Finally, the third part regards the attemps to synthesize the indenic privileged structure as a strategy to obtain the natural product Cyanosporoside.
Autorenporträt
Lorenzo Botta desde 2013 trabalha na Universidade de Nápoles com o Prof. Novellino. Obteve o seu doutoramento na Universidade de Siena em 2010. Durante o seu doutoramento, passou três meses na ETH de Zurique com o Prof. Altmann e um ano na TSRI em San Diego com o Prof. Nicolaou. Em 2012 passou um ano na Universidade de Columbia, em Nova Iorque, com o Prof. Snyder.