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Benzofurans are universal in the landscape, especially in the herbal plant Kingdom. Frequently such naturals with benzofuran basis are gifted with useful pharmacological properties. This has created huge enthusiasm for artificial products containing Benzofurans and brought the improvement of chemistry in benzofuran molecules chemistry throughout the last several decades.Benzofuran occurs in nature as diversity in structural nature, ranging from a small nucleus like 5-methoxybenzofuran to a greatly complex molecule such as morphine.