Systemic lupus Erythematosus is chronic autoimmune connective tissue disorder with a heterogeneous presentation that affects many organs of the body. Though it is present among the Nigerian population, Little attention has been given to it. The study determined the prevalence of systemic lupus erythematosus and it's association with antinuclear antibody and extractable nuclear antigen in some patients attending selected hospitals in Zaria Kaduna State, Nigeria and a questionnaire used to obtain some socio-demographic and risk factors of the disease from the study population.