This open-access textbook is an excellent introduction to systems biology, which has developed rapidly in recent years. It discusses the processes in living organisms in an integrated way, enabling the reader to understand the fundamental principles and cause-effect relationships in biology and biochemistry. The authors have chosen an original but at the same time clear way of presenting the topics, repeatedly drawing comparisons and models from the macroscopic world and making the reader aware of the unity of the laws of physics, chemistry and biology. The fully updated 2nd edition also…mehr
This open-access textbook is an excellent introduction to systems biology, which has developed rapidly in recent years. It discusses the processes in living organisms in an integrated way, enabling the reader to understand the fundamental principles and cause-effect relationships in biology and biochemistry. The authors have chosen an original but at the same time clear way of presenting the topics, repeatedly drawing comparisons and models from the macroscopic world and making the reader aware of the unity of the laws of physics, chemistry and biology.
The fully updated 2nd edition also contains information that has only become available as a result of the increase in knowledge in recent years. This includes information on tumorigenesis, where significant progress has been made due to the explosive development of genetic knowledge as well as bioengineering with a highly effective technique adopted from the solutions of the bacterial world, such as CRISPR/CAS.
Thisrichly illustrated book is essential for postgraduate students and scientists of the following disciplines: biology, biotechnology, medicine, bioinformatics, robotics and automation, biocybernetics, and biomedical engineering. It is also an exciting read for anyone interested in biology.
Prof. emeritus Leszek Konieczny, MD, is Professor of Biochemistry at the Medical College of Jagiellonian University, Poland. His background is in medicine and his research focuses on immunochemistry and target-oriented drug transport. He is the author of numerous scientific papers in the field of protein structure, function and immunochemistry. He teaches biochemistry to medical students and has authored several textbooks on systems biology and protein structure. Prof. Irena Roterman-Konieczna, PhD, is Professor of Medical Sciences at the Medical College of Jagiellonian University, Poland. Her background is in bioinformatics and theoretical chemistry. She was included in 2020, 2021 and 2022 on the Stanford World Ranking Top 2% Scientists. Her scientific interests focus on protein structure, function and amyloidosis. She is involved in numerous international scientific collaborations and is the Polish Chief of the EuChinaGrid network. She has authored highly successful textbooks for medical and life sciences students interested in learning about simulations in medicine, bioinformatics, statistics and systems biology. Pawe¿ Spólnik, MD, PhD, obtained his PhD in 2005 at the Medical College, Jagiellonian University, Poland. He studied medicine at the Faculty of Medicine of Jagiellonian University and specialised in internal medicine and cardiology. Currently, he works as an Interventional Cardiologist in Germany.
Inhaltsangabe
Chapter 1: The Structure And Function Of Living Organisms.- Chapter 2: Energy In Biology - Demand And Use.- Chapter 3: Information - Its Role And Meaning In Organism.- Chapter 4: Regulation In Biological Systems.- Chapter 5: Interrelationship In Organized Biological Systems.
Chapter 1: The Structure And Function Of Living Organisms. Chapter 2: Energy In Biology Demand And Use. Chapter 3: Information Its Role And Meaning In Organism. Chapter 4: Regulation In Biological Systems. Chapter 5: Interrelationship In Organized Biological Systems.
The Structure and Function of Living Organisms.- General physiochemical properties of biological structures.- Self-organization.- Hypothesis - Protein folding simulation hypothesis - late stage intermediate – role of water.- Energy in Biology – Demand and Use.- General principles of thermodynamics.- Biological energy sources – synthesis of water.- ATP synthesis.- Photosynthesis.- Direct and indirect exploitation of energy sources.- Energy conversion efficiency in biological processes.- Entropic effects.- Energy requirements of organisms.- Information – Its Role and Meaning in Organisms.- Information as a quantitative concept. - Reliability of information sources.- Types of information conveyed by DNA.- Information entropy and mechanisms assisting selection.- The role of information in interpreting pathological events.- Hypothesis - Protein folding early stage intermediate.- Regulation in Biological Systems.- The cell and the organism.- The principle and mechanism of automatic intracellular regulation.- Regulatory coupling between cells and organisms – hierarchical properties of regulation.- Regulatory mechanisms on the organism level.- Basic principles of regulation in biology.- Regulation levels.- Hypothesis - Proteome construction hypothesis.- Interrelationships in Organized Biological Systems.- The need of mutual relations in biological systems.- Cooperation and coordination.- The characteristics of process coordination in individual cells and organisms.- Mutual relationship between cells and the organism – activation and inhibition of enzymes (rapid effects).- Mutual support between cells and the organism – interdependence related to gene expression (slow effects).- Specialization of cell interrelationships.- Hypothesis - The criteria of life.
Chapter 1: The Structure And Function Of Living Organisms.- Chapter 2: Energy In Biology - Demand And Use.- Chapter 3: Information - Its Role And Meaning In Organism.- Chapter 4: Regulation In Biological Systems.- Chapter 5: Interrelationship In Organized Biological Systems.
Chapter 1: The Structure And Function Of Living Organisms. Chapter 2: Energy In Biology Demand And Use. Chapter 3: Information Its Role And Meaning In Organism. Chapter 4: Regulation In Biological Systems. Chapter 5: Interrelationship In Organized Biological Systems.
The Structure and Function of Living Organisms.- General physiochemical properties of biological structures.- Self-organization.- Hypothesis - Protein folding simulation hypothesis - late stage intermediate – role of water.- Energy in Biology – Demand and Use.- General principles of thermodynamics.- Biological energy sources – synthesis of water.- ATP synthesis.- Photosynthesis.- Direct and indirect exploitation of energy sources.- Energy conversion efficiency in biological processes.- Entropic effects.- Energy requirements of organisms.- Information – Its Role and Meaning in Organisms.- Information as a quantitative concept. - Reliability of information sources.- Types of information conveyed by DNA.- Information entropy and mechanisms assisting selection.- The role of information in interpreting pathological events.- Hypothesis - Protein folding early stage intermediate.- Regulation in Biological Systems.- The cell and the organism.- The principle and mechanism of automatic intracellular regulation.- Regulatory coupling between cells and organisms – hierarchical properties of regulation.- Regulatory mechanisms on the organism level.- Basic principles of regulation in biology.- Regulation levels.- Hypothesis - Proteome construction hypothesis.- Interrelationships in Organized Biological Systems.- The need of mutual relations in biological systems.- Cooperation and coordination.- The characteristics of process coordination in individual cells and organisms.- Mutual relationship between cells and the organism – activation and inhibition of enzymes (rapid effects).- Mutual support between cells and the organism – interdependence related to gene expression (slow effects).- Specialization of cell interrelationships.- Hypothesis - The criteria of life.
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