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On the discussed topic, the author has summarized and logically interpreted the results of experimental and clinical studies in this area. Throughout the course of scientific research, a notable discovery emerged: an undisclosed natural phenomenon - the infiltration of gastric juice through the ulcer defect in the walls of the stomach and duodenum in patients with peptic ulcer disease. Additionally, the author uncovered two new phenomena in the world around us - the pathogenesis of peptic ulcer disease and the interconnectedness of the folds of the mucous membrane of the stomach, the wall liquor of gastric juice, and the frequent localization of ulcers on the small curvature of the stomach and the upper semicircle of the bulb of the duodenum. Moreover, an original method of treating chronic gastroduodenal ulcers is proposed - endoscopic autohemoapplication of the ulcer. The book holds great practical value, simultaneously reinforcing the theoretical aspects of the doctrine of peptic ulcer disease and making a significant contribution to fundamental gastroenterology.