The only guide for the public to the science and history of Alzheimer’s disease. This book can help you if you fear that you have Alzheimer’s disease or if a friend or family member has Alzheimer’s disease.
The only guide for the public to the science and history of Alzheimer’s disease. This book can help you if you fear that you have Alzheimer’s disease or if a friend or family member has Alzheimer’s disease.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
TABLE OF CONTENTS Preface Prologue Part I – Alois & Auguste (and a bit of Oskar) Chapter 1 – Dr Hoffmann’s vision Chapter 2 – Mrs Deter Chapter 3 – Alois Alzheimer Chapter 4 – Munich via Heidelberg Chapter 5 – 1906 Chapter 6 – The Tübingen aftermath Chapter 7 – Fischer’s disease Chapter 8 – Alzheimer’s legacy Part I – Summary Part II – Memory and Space Chapter 9 – ‘You are not my type’ Chapter 10 – The art of memory Chapter 11 – ‘Secret’ memory techniques Chapter 12 – ‘Attention!’” Chapter 13 – ‘Enter the seahorse’ Chapter 14 – Encoding, storage, retrieval Chapter 15 – ‘It’s all about access’ Chapter 16 – The imaginary Mrs A Chapter 17 – Spatial Disorientation Chapter 18 – ‘Lost in space’ Part II – Summary Part III – Amyloid and Tau Chapter 19 – Glorious proteins Chapter 20 – Amyloid Chapter 21 – Beta-amyloid formation Chapter 22 – ‘Location, location, location… and timing’ Chapter 23 – Tau Chapter 24 – ‘Who ordered all the phosphate?’ Chapter 25 – Tau ‘infection’ Chapter 26 – Amyloid versus Tau Chapter 27 – The ‘emergence’ of the disease Chapter 28 – Biomarker technology Chapter 29 – Amyloid treatment approaches Decreasing beta-amyloid production Prevention of beta-amyloid accumulation Increase of beta-amyloid removal Chapter 30 – Tau treatment approaches Decrease of overall tau Decrease of tau phosphorylation Decrease phosphorylated tau accumulation Increase phosphorylated tau removal Chapter 31 – Why have drug trials failed so far? Phase I Phase II Phase III Part III – Summary Part IV – Genetics and lifestyle Chapter 32 – Genetics 101 Chapter 33 – Familial Alzheimer’s disease APP PSEN MAPT Chapter 34 – ‘Modifiable’ risk genes APOE TREM2 Chapter 35 – A word on genetic testing Chapter 36 – Non-modifiable lifestyle factors Age Education Hearing loss Chapter 37 – Modifiable lifestyle factors Diabetes, hypertension and obesity Physical activity Diet and nutrition Sleep Other modifiable lifestyle risk factors Part IV – Summary Part V – Rarer forms of Alzheimer’s disease Chapter 38 – Frontal variant Alzheimer’s disease Chapter 39 – Posterior Cortical Atrophy Chapter 40 – Logopenic variant primary progressive aphasia Chapter 41 – Corticobasal syndrome Chapter 42 – A final word on the rarer forms of Alzheimer’s disease Part V – Summary Epilogue Further country specific links (English language) Index
TABLE OF CONTENTS Preface Prologue Part I – Alois & Auguste (and a bit of Oskar) Chapter 1 – Dr Hoffmann’s vision Chapter 2 – Mrs Deter Chapter 3 – Alois Alzheimer Chapter 4 – Munich via Heidelberg Chapter 5 – 1906 Chapter 6 – The Tübingen aftermath Chapter 7 – Fischer’s disease Chapter 8 – Alzheimer’s legacy Part I – Summary Part II – Memory and Space Chapter 9 – ‘You are not my type’ Chapter 10 – The art of memory Chapter 11 – ‘Secret’ memory techniques Chapter 12 – ‘Attention!’” Chapter 13 – ‘Enter the seahorse’ Chapter 14 – Encoding, storage, retrieval Chapter 15 – ‘It’s all about access’ Chapter 16 – The imaginary Mrs A Chapter 17 – Spatial Disorientation Chapter 18 – ‘Lost in space’ Part II – Summary Part III – Amyloid and Tau Chapter 19 – Glorious proteins Chapter 20 – Amyloid Chapter 21 – Beta-amyloid formation Chapter 22 – ‘Location, location, location… and timing’ Chapter 23 – Tau Chapter 24 – ‘Who ordered all the phosphate?’ Chapter 25 – Tau ‘infection’ Chapter 26 – Amyloid versus Tau Chapter 27 – The ‘emergence’ of the disease Chapter 28 – Biomarker technology Chapter 29 – Amyloid treatment approaches Decreasing beta-amyloid production Prevention of beta-amyloid accumulation Increase of beta-amyloid removal Chapter 30 – Tau treatment approaches Decrease of overall tau Decrease of tau phosphorylation Decrease phosphorylated tau accumulation Increase phosphorylated tau removal Chapter 31 – Why have drug trials failed so far? Phase I Phase II Phase III Part III – Summary Part IV – Genetics and lifestyle Chapter 32 – Genetics 101 Chapter 33 – Familial Alzheimer’s disease APP PSEN MAPT Chapter 34 – ‘Modifiable’ risk genes APOE TREM2 Chapter 35 – A word on genetic testing Chapter 36 – Non-modifiable lifestyle factors Age Education Hearing loss Chapter 37 – Modifiable lifestyle factors Diabetes, hypertension and obesity Physical activity Diet and nutrition Sleep Other modifiable lifestyle risk factors Part IV – Summary Part V – Rarer forms of Alzheimer’s disease Chapter 38 – Frontal variant Alzheimer’s disease Chapter 39 – Posterior Cortical Atrophy Chapter 40 – Logopenic variant primary progressive aphasia Chapter 41 – Corticobasal syndrome Chapter 42 – A final word on the rarer forms of Alzheimer’s disease Part V – Summary Epilogue Further country specific links (English language) Index
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