Taste Masked Oral Disintegrating Tablet Dosage Form - Satapara, Vijay;Satapara, Rahul
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The purpose of this research was to mask the intensely bitter taste of Lumefantrine and to formulate oral-disintegrating tablet (ODT) of Artemether & Lumefantrine. Taste masking was done by complexing Lumefantrine with amino alkyl methacrylate copolymer (Eudragit E - 100) using solvent deposition method and acetone as a solvent for pH-sensitive polymer and was tested for drug content and in vitro taste in simulated salivary fluid (SSF) of pH 6.8. The complex with drug polymer ratio of 1: 0.1 that did not release drug in SSF was considered taste-masked and selected for formulation of ODTs.

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Produktbeschreibung
The purpose of this research was to mask the intensely bitter taste of Lumefantrine and to formulate oral-disintegrating tablet (ODT) of Artemether & Lumefantrine. Taste masking was done by complexing Lumefantrine with amino alkyl methacrylate copolymer (Eudragit E - 100) using solvent deposition method and acetone as a solvent for pH-sensitive polymer and was tested for drug content and in vitro taste in simulated salivary fluid (SSF) of pH 6.8. The complex with drug polymer ratio of 1: 0.1 that did not release drug in SSF was considered taste-masked and selected for formulation of ODTs.
Autorenporträt
Mr.Vijay Satapara obtained his M.pharma. degree in Pharmaceutics From Saurashtra university in 2010. He has completed his post graduate diploma in patent law from nalsar university,Hyderabad. He is doing phD From JJT university, Rajasthan. Currently he is working with Torrent Research Center as scientist in Regulatory Affairs Department.