KAYUMBA PIERRE CLAVER

TASTE - MASKED QUININE PELLETS FOR FLEXIBLE PEDIATRIC DRUG DOSING

IN ORAL TREATMENT OF MALARIA

• Broschiertes Buch

Produktbeschreibung

The lack of pediatric drug formulation for the existing as well as new molecules is a worldwide concern. Pediatricians are forced to fragment adults' dosage forms. For quinine, tablets (200 or 300 mg quinine sulphate)are broken to get pediatric doses. The author observed weight variations when quinine tablets were broken into halves and quarters and proposed pellets as alternative to tablet breaking since they offer more flexibility for the dose adaptation to the child body weight. Taste-masked pellets of 300 700 µm of diameter have been produced. The bioavailability of quinine formulated as taste-masked pellets was good compared to the tablets on the market. Quinine efficacy was assessed in 56 children under five years' age. The mean Parasitaemia Clearance Time (PCT) was 72.8 ± 16.5 h. Concentrations during steady state (10.4 ± 2.1-14.9 ± 1.0 µg/ml)were in the therapeutic range. No treatment failure was observed, making thereby taste-masked quinine sulphate pellets a means for flexible dose adaptation to the body weight of children during malaria treatment.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 156
• Erscheinungstermin: 14. April 2011
• Englisch
• Abmessung: 220mm x 150mm x 10mm
• Gewicht: 250g
• ISBN-13: 9783844327021
• ISBN-10: 3844327029
• Artikelnr.: 33315759

Autorenporträt

Dr. KAYUMBA Pierre Claver holds a PhD in Pharmaceutical Sciences from Ghent University and he is Senior Lecturer of Drug Analysis and Quality Control, is currently the Vice-Dean for Post-Graduate Studies, Consultancy and Research at the Faculty of Medicine of the National University of Rwanda.