High Quality Content by WIKIPEDIA articles! High Quality Content by WIKIPEDIA articles! Temperature Gradient Gel Electrophoresis (TGGE) and Denaturing Gradient Gel Electrophoresis (DGGE) are forms of electrophoresis where there is a temperature or chemical gradient across the gel. TGGE and DGGE are useful for analyzing nucleic acids such as DNA and RNA, and sometimes for proteins. TGGE is one of a family of electrophoretic methods for separation of nucleic acids like DNA or RNA that rely on temperature dependent changes in structure; the original method was DGGE, which is almost identical. DGGE was invented by Leonard Lerman, while he was a professor at SUNY Albany.