Originating from a renowned course on receptor pharmacology, this text presents in-depth coverage of this rapidly expanding research area. The book combines current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms. It focuses on molecular investigation of receptor structure, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction at the cell membrane. This edition includes updated chapters on receptor structure and signal transduction by…mehr
Originating from a renowned course on receptor pharmacology, this text presents in-depth coverage of this rapidly expanding research area. The book combines current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms. It focuses on molecular investigation of receptor structure, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction at the cell membrane. This edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions.Hinweis: Dieser Artikel kann nur an eine deutsche Lieferadresse ausgeliefert werden.
John C. Foreman, Ph.D., D.Sc., M.B., B.S., F.R.C.P., is emeritus professor of pharmacology at University College London. His research interests have included the role of bradykinin receptors in the human nasal airway, the control of microvascular circulation in human skin, and the mechanism of activation of dendritic cells. He has published reviews, contributions to books, and 170 research papers. Torben Johansen, M.D., Dr. Med. Sci. is a docent of pharmacology at the University of Southern Denmark. He has published 70 research papers in refereed journals. His current major research interests are N-methyl-D-aspartate (NMDA) receptors in the stubstantia nigra in relation to cell death in Parkinson's disease and also ion transport and signaling in mast cells in relation to intracellular pH and volume regulation. Alasdair Gibb, B.Sc., Ph.D., is reader in pharmacology at University College London. He currently leads the General and Advanced Receptor Theory Workshop of the British Pharmacological Society Diploma in Pharmacology and is a course leader on the British Pharmacological Society short course on Translational Pharmacology.
Inhaltsangabe
Drug-Receptor Interactions: Classical Approaches to the Study of Drug-Receptor Interactions. Molecular Structure of Receptors: Structure and Function 7-TM G-Protein Coupled Receptors. The Structure of Ligand-Gated Ion Channels. Molecular Structure of Receptor Tyrosine Kinases. Ligand-Binding Studies of Receptors: Direct Measurement of Drug Binding to Receptors. Transduction of the Receptor Signal: Receptors Linked to Ion Channels: Mechanisms of Activation and Block. G-Proteins. Signal Transduction through Protein Tyrosine Kinases. Receptors as Pharmaceutical Targets: Receptors as Pharmaceutical Targets.
Drug-Receptor Interactions: Classical Approaches to the Study of Drug-Receptor Interactions. Molecular Structure of Receptors: Structure and Function 7-TM G-Protein Coupled Receptors. The Structure of Ligand-Gated Ion Channels. Molecular Structure of Receptor Tyrosine Kinases. Ligand-Binding Studies of Receptors: Direct Measurement of Drug Binding to Receptors. Transduction of the Receptor Signal: Receptors Linked to Ion Channels: Mechanisms of Activation and Block. G-Proteins. Signal Transduction through Protein Tyrosine Kinases. Receptors as Pharmaceutical Targets: Receptors as Pharmaceutical Targets.
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