John C. Foreman / Torben Johansen / Alasdair J. Gibb (Hrsg.)

Textbook of Receptor Pharmacology

Herausgeber: Foreman, John C; Gibb, Alasdair J; Johansen, Torben

• Gebundenes Buch

Produktbeschreibung

Originating from a renowned course on receptor pharmacology, this text presents in-depth coverage of this rapidly expanding research area. The book combines current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms. It focuses on molecular investigation of receptor structure, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction at the cell membrane. This edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions.

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Produktdetails

• Verlag: CRC Press
• 3rd edition
• Seitenzahl: 312
• Erscheinungstermin: 7. September 2010
• Englisch
• Abmessung: 257mm x 180mm x 23mm
• Gewicht: 816g
• ISBN-13: 9781420052541
• ISBN-10: 1420052543
• Artikelnr.: 21971521

Autorenporträt

John C. Foreman, Ph.D., D.Sc., M.B., B.S., F.R.C.P., is emeritus professor of pharmacology at University College London. His research interests have included the role of bradykinin receptors in the human nasal airway, the control of microvascular circulation in human skin, and the mechanism of activation of dendritic cells. He has published reviews, contributions to books, and 170 research papers. Torben Johansen, M.D., Dr. Med. Sci. is a docent of pharmacology at the University of Southern Denmark. He has published 70 research papers in refereed journals. His current major research interests are N-methyl-D-aspartate (NMDA) receptors in the stubstantia nigra in relation to cell death in Parkinson's disease and also ion transport and signaling in mast cells in relation to intracellular pH and volume regulation. Alasdair Gibb, B.Sc., Ph.D., is reader in pharmacology at University College London. He currently leads the General and Advanced Receptor Theory Workshop of the British Pharmacological Society Diploma in Pharmacology and is a course leader on the British Pharmacological Society short course on Translational Pharmacology.

Inhaltsangabe

Drug-Receptor Interactions: Classical Approaches to the Study of
Drug-Receptor Interactions. Molecular Structure of Receptors: Structure and
Function 7-TM G-Protein Coupled Receptors. The Structure of Ligand-Gated
Ion Channels. Molecular Structure of Receptor Tyrosine Kinases.
Ligand-Binding Studies of Receptors: Direct Measurement of Drug Binding to
Receptors. Transduction of the Receptor Signal: Receptors Linked to Ion
Channels: Mechanisms of Activation and Block. G-Proteins. Signal
Transduction through Protein Tyrosine Kinases. Receptors as Pharmaceutical
Targets: Receptors as Pharmaceutical Targets.