Dental caries which is very commonly known as "tooth decay" is not a new disease to mankind. In ancient population, evidence of dental caries were found but now a days it has become more significant, this could be because of urbanization of civilization. Dental caries represents a significant proportion of the daily routine for many practicing clinician. Recently we have entered an era where concept of "prevention" has taken place. This book aims at reviewing as well as upgrading the present text accessible on dental caries vaccination encompassing its role in caries prevention as well as escorting its safe and ill effects, as this may contribute to the existing knowledge on the topic.